接受辅助生殖技术治疗的不孕妇女体内正常范围的游离甲状腺素浓度与卵巢储备功能之间的关系。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Qiaoling Zhang, Dandan Zhang, Haoyuan Liu, Jinyun Fu, Li Tang, Meng Rao
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引用次数: 0

摘要

背景:最近的一些研究表明,女性亚临床甲状腺功能减退症(SCH)与卵巢储备功能降低(DOR)有关。本研究旨在探讨血清游离甲状腺素(fT4)浓度在参考范围内是否与女性卵巢储备功能有关:这项横断面研究纳入了4933名fT4浓度在正常范围内的不孕妇女,她们都在本诊所接受了辅助生殖技术治疗。将不同fT4浓度三分位数(即12-15.33、15.34-18.67和18.68-22 pmol/L)妇女的数据与卵巢储备标志物(即抗穆勒氏管激素(AMH)浓度、前卵泡计数(AFC)和抽取的卵母细胞数)进行了比较。主要结果是 AMH 浓度和 DOR 风险(诊断为 AMH 浓度结果):低正常、中正常和高正常 fT4 三元组妇女的平均年龄分别为 33.20(标准差 [SD]:5.11)、32.33(标准差:5.13)和 31.61(标准差:5.10)岁(P 结论:低正常、中正常和高正常 fT4 三元组妇女的平均年龄为 33.20(标准差 [SD]:5.11)、32.33(标准差:5.13)和 31.61(标准差:5.10)岁:低正常 fT4 浓度与不孕妇女较低的卵巢储备功能有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations between a normal-range free thyroxine concentration and ovarian reserve in infertile women undergoing treatment via assisted reproductive technology.

Background: Some recent studies have shown that female subclinical hypothyroidism (SCH) is associated with diminished ovarian reserve (DOR). In this study, we aimed to investigate whether serum-free thyroxine (fT4) concentrations within the reference range are associated with ovarian reserve in women.

Methods: This cross-sectional study included 4933 infertile women with normal-range fT4 concentrations who received assisted reproductive technology treatment in our clinic. The data of women in different fT4 concentration tertiles (namely 12-15.33, 15.34-18.67, and 18.68-22 pmol/L) were compared with ovarian reserve markers, namely the anti-Müllerian hormone (AMH) concentration, the antral follicle count (AFC), and the number of aspirated oocytes. The primary outcomes were the AMH concentration and the risk of DOR, diagnosed as an AMH concentration < 1.1 ng/mL.

Results: The average ages of women in the low-normal, middle-normal, and high-normal fT4 tertiles were 33.20 (standard deviation [SD]: 5.11), 32.33 (SD: 5.13), and 31.61 (SD: 5.10) years, respectively (p < 0.0001). AMH concentrations (adjusted mean: 3.32 [95% confidence interval {CI}: 3.16 to 3.50] vs. 3.51 [3.40 to 3.62] vs. 3.64 [3.50 to 3.80] ng/mL, p = 0.022) were significantly different between the fT4 concentration tertiles. The risk of DOR was significantly increased in the low-normal (adjusted odds ratio: 1.61 [95% CI: 1.01 to 2.58]) and middle-normal (1.47 [95% CI: 1.00 to 2.16]) tertiles compared with the high-normal tertile. Subgroup analysis showed that AMH concentrations were significantly different among the fT4 concentration tertiles in women aged < 35 years (adjusted mean: 3.94 [95% CI: 3.70 to 4.20] vs. 4.25 [4.11 to 4.39] vs. 4.38 [4.18 to 4.58], p = 0.028), whereas this difference was not significant in women aged ≥ 35 years (p = 0.534). The general additive models using fT4 as a continuous variable indicated that a lower fT4 concentration within the normal range was significantly associated with a lower AMH concentration (p = 0.027), a lower AFC (p = 0.018), a lower number of aspirated oocytes (p = 0.001), and a higher risk of DOR (p = 0.007).

Conclusion: Low-normal fT4 concentrations are associated with lower ovarian reserve in infertile women.

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来源期刊
Reproductive Biology and Endocrinology
Reproductive Biology and Endocrinology 医学-内分泌学与代谢
CiteScore
7.90
自引率
2.30%
发文量
161
审稿时长
4-8 weeks
期刊介绍: Reproductive Biology and Endocrinology publishes and disseminates high-quality results from excellent research in the reproductive sciences. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive immunology, neuroendocrinology, and veterinary and human reproductive medicine, including all vertebrate species.
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