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引用次数: 0
摘要
研究表明，成骨细胞中的线粒体在骨形成过程中发挥着多种重要功能，包括细胞内 ATP 的产生和细胞外线粒体成分的分泌。本综述探讨了目前有关成骨细胞线粒体生物学的知识，包括线粒体生物生成、生物能、氧化应激生成和形态的动态变化。我们还特别关注了最近的研究发现，包括成骨细胞中线粒体甜甜圈的形成，它能积极生成线粒体衍生囊泡 (MDV)，随后小线粒体和 MDV 在细胞外分泌。我们还讨论了针对成骨细胞线粒体的治疗效果，强调了它们在改善骨骼健康方面的潜在应用。
The multifaceted roles of mitochondria in osteoblasts: from energy production to mitochondrial-derived vesicle secretion.
Mitochondria in osteoblasts have been demonstrated to play multiple crucial functions in bone formation from intracellular adenosine triphosphate production to extracellular secretion of mitochondrial components. The present review explores the current knowledge about mitochondrial biology in osteoblasts, including mitochondrial biogenesis, bioenergetics, oxidative stress generation, and dynamic changes in morphology. Special attention is given to recent findings, including mitochondrial donut formation in osteoblasts, which actively generates mitochondrial-derived vesicles (MDVs), followed by extracellular secretion of small mitochondria and MDVs. We also discuss the therapeutic effects of targeting osteoblast mitochondria, highlighting their potential applications in improving bone health.
期刊介绍：
The Journal of Bone and Mineral Research (JBMR) publishes highly impactful original manuscripts, reviews, and special articles on basic, translational and clinical investigations relevant to the musculoskeletal system and mineral metabolism. Specifically, the journal is interested in original research on the biology and physiology of skeletal tissues, interdisciplinary research spanning the musculoskeletal and other systems, including but not limited to immunology, hematology, energy metabolism, cancer biology, and neurology, and systems biology topics using large scale “-omics” approaches. The journal welcomes clinical research on the pathophysiology, treatment and prevention of osteoporosis and fractures, as well as sarcopenia, disorders of bone and mineral metabolism, and rare or genetically determined bone diseases.
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