父母患有偏头痛的后代患重大精神障碍的风险。

IF 3.6 3区 医学 Q1 PSYCHIATRY
Dian-Jeng Li, Shih-Jen Tsai, Tzeng-Ji Chen, Chih-Sung Liang, Mu-Hong Chen
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引用次数: 0

摘要

背景:偏头痛与精神障碍有关,但父母偏头痛是否与后代患主要精神障碍(MMDs)的风险增加有关,尚未进行过研究。我们的目的是研究父母患有偏头痛与父母没有偏头痛相比,其后代患重大精神障碍的风险:本研究使用的数据来自台湾国民健康保险研究数据库。方法:本研究使用了来自台湾国民健康保险研究数据库的数据,纳入了患有偏头痛的父母的后代和由无偏头痛的父母的后代组成的对照组,对照组在人口统计学和父母精神障碍方面匹配。采用Cox回归估算偏头痛后代患精神疾病的风险,包括精神分裂症、抑郁障碍、双相情感障碍、自闭症谱系障碍(ASD)和注意力缺陷/多动障碍(ADHD)。我们还进一步对父亲和母亲进行了分层分析,以分别明确后代中罹患MMDs的风险:我们纳入了 22,747 名父母患有偏头痛的后代和 227,470 名父母没有偏头痛的后代作为对照。与没有偏头痛的父母的后代相比,父母偏头痛与多动症(ADHD)(报告为危险比,95%置信区间:1.37,1.25-1.50)、双相情感障碍(1.35,1.06-1.71)和抑郁障碍(1.33,1.21-1.47)的患病风险增加有明显关联。重要的是,子分析表明,只有母亲偏头痛与这些风险显著相关:结论:由于偏头痛的负担沉重,医护人员应注意父母患有偏头痛的后代患偏头痛的风险,尤其是母亲。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk of major mental disorders in the offspring of parents with migraine.

Background: Migraine has been associated with mental disorders, however whether parental migraine is associated with an increased risk of major mental disorders (MMDs) in offspring has not been investigated. We aimed to examine the risk of the development of MMDs in the offspring of parents with migraine compared with those of parents without migraine.

Methods: This study used data derived from the Taiwan National Health Insurance Research Database. Offspring of parents with migraine and a control group consisting of offspring of parents without migraine matched for demographic and parental mental disorders were included. Cox regression was used to estimate the risk of MMDs, including schizophrenia, depressive disorder, bipolar disorder, autistic spectrum disorder (ASD), and attention deficit/hyperactivity disorder (ADHD). Sub-analyses stratified by the fathers and mothers were further performed to separately clarify the risks of MMDs among the offspring.

Results: We included 22,747 offspring of parents with migraine and 227,470 offspring of parents without migraine as the controls. Parental migraine was significantly associated with an increased risk of ADHD (reported as hazard ratios with 95% confidence intervals: 1.37, 1.25-1.50), bipolar disorder (1.35, 1.06-1.71), and depressive disorder (1.33, 1.21-1.47) compared to the offspring of parents without migraine. Importantly, sub-analyses showed that only maternal migraine was significantly associated with these risks.

Conclusions: Due to the heavy burden of MMDs, healthcare workers should be aware of the risk of MMDs in the offspring of parents with migraine, particular in mothers.

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来源期刊
CiteScore
6.60
自引率
2.70%
发文量
43
审稿时长
>12 weeks
期刊介绍: Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.
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