甲状腺乳头状癌侧颈淋巴结转移的风险因素分析：一项对830名患者的回顾性研究。

IF 2.5 3区医学 Q3 ONCOLOGY

World Journal of Surgical Oncology Pub Date : 2024-06-21 DOI:10.1186/s12957-024-03455-w

Haifeng Zhong, Qingxin Zeng, Xi Long, Yeqian Lai, Jiwei Chen, Yuedong Wang

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引用次数: 0

摘要

研究目的本研究旨在探讨甲状腺乳头状癌（PTC）颈侧淋巴结转移的风险因素：收集梅州市人民医院2021年6月至2023年4月期间诊治的830例PTC患者的临床病理资料（年龄、性别、桥本氏甲状腺炎、术前循环肿瘤细胞（CTC）、多灶性、病灶最大直径、浸润囊、T期、淋巴结转移）。分析了颈侧淋巴结转移的相关因素：结果：中心淋巴结转移和颈侧淋巴结转移的PTC患者分别为334例（40.2%）和103例（12.4%）。与无侧颈淋巴结转移的患者相比，有侧颈淋巴结转移的PTC患者多灶性、病灶最大直径大于1厘米、侵犯囊膜、T3-T4分期的比例较高。回归逻辑分析表明，男性（几率比（OR）：2.196，95% 置信区间（CI）：1.279-3.769，P = 0.004）、年龄 1 厘米（OR：5.408，95% CI：3.233-9.046，P 结论：男性、年龄 1 厘米、T3-T4 期、T3-T4 期、T3-T4 期、T3-T4 期、T3-T4 期、T3-T4 期、T3-T4 期男性、年龄1厘米、T3-T4分期和侵犯囊膜是PTC侧颈部淋巴结转移的独立危险因素。

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Risk factors analysis of lateral cervical lymph node metastasis in papillary thyroid carcinoma: a retrospective study of 830 patients.

Objective: The aim of this study is to investigate the risk factors for lateral cervical lymph node metastasis in papillary thyroid carcinoma (PTC).

Methods: Clinicopathological data (age, gender, Hashimoto's thyroiditis, preoperative circulating tumor cells (CTCs), multifocal, maximum lesion diameter, invaded capsule, T stage, and lymph node metastasis) of 830 PTC patients diagnosed and treated in Meizhou People's Hospital from June 2021 to April 2023 were collected. The related factors of lateral cervical lymph node metastasis were analyzed.

Results: There were 334 (40.2%), and 103 (12.4%) PTC patients with central lymph node metastasis, and lateral cervical lymph node metastasis, respectively. Compared with patients without lateral cervical lymph node metastasis, PTC patients with lateral cervical lymph node metastasis had a higher proportion of multifocal, maximum lesion diameter > 1 cm, invaded capsule, T3-T4 stage. Regression logistic analysis showed that male (odds ratio (OR): 2.196, 95% confidence interval (CI): 1.279-3.769, p = 0.004), age < 55 years old (OR: 2.057, 95% CI: 1.062-3.988, p = 0.033), multifocal (OR: 2.759, 95% CI: 1.708-4.458, p < 0.001), maximum lesion diameter > 1 cm (OR: 5.408, 95% CI: 3.233-9.046, p < 0.001), T3-T4 stage (OR: 2.396, 95% CI: 1.241-4.626, p = 0.009), and invaded capsule (OR: 2.051, 95% CI: 1.208-3.480, p = 0.008) were associated with lateral cervical lymph node metastasis.

Conclusions: Male, age < 55 years old, multifocal, maximum lesion diameter > 1 cm, T3-T4 stage, and invaded capsule were independent risk factors for lateral cervical lymph node metastasis in PTC.

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来源期刊

World Journal of Surgical Oncology ONCOLOGY-SURGERY

CiteScore

4.70

自引率

15.60%

发文量

362

审稿时长

3 months

期刊介绍： World Journal of Surgical Oncology publishes articles related to surgical oncology and its allied subjects, such as epidemiology, cancer research, biomarkers, prevention, pathology, radiology, cancer treatment, clinical trials, multimodality treatment and molecular biology. Emphasis is placed on original research articles. The journal also publishes significant clinical case reports, as well as balanced and timely reviews on selected topics. Oncology is a multidisciplinary super-speciality of which surgical oncology forms an integral component, especially with solid tumors. Surgical oncologists around the world are involved in research extending from detecting the mechanisms underlying the causation of cancer, to its treatment and prevention. The role of a surgical oncologist extends across the whole continuum of care. With continued developments in diagnosis and treatment, the role of a surgical oncologist is ever-changing. Hence, World Journal of Surgical Oncology aims to keep readers abreast with latest developments that will ultimately influence the work of surgical oncologists.