早期和持久：以内皮为目标，保护血脑屏障。

IF 4.9 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-06-21 DOI:10.1177/0271678X241264086

Silin Wu, Xuefang Sophie Ren, Yejie Shi

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引用次数: 0

摘要

血脑屏障的破坏是缺血性中风的一个关键性早期病理事件，对随后的永久性损伤起着重要作用。徐及其同事的研究强调了过氧化物歧化酶-4 蛋白在脑血管内皮细胞中的重要作用。研究表明，过氧化物歧化酶-4 能在脑缺血和再灌注后的早期阶段保护血脑屏障的完整性，最终改善长期预后。

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Early and enduring: Targeting the endothelium for blood-brain barrier protection.

The disruption of the blood-brain barrier marks a pivotal early pathological event in ischemic stroke that significantly contributes to subsequent permanent damage. Here we delve into the ramifications of a study conducted by Xu and colleagues, which underscores the essential role of the protein peroxiredoxin-4 in cerebrovascular endothelial cells. Peroxiredoxin-4 was shown to preserve blood-brain barrier integrity during the early stages after cerebral ischemia and reperfusion, ultimately leading to improved long-term outcomes.

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来源期刊

Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.80%

发文量

300

审稿时长

3 months

期刊介绍： JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.