抗代谢药方案对实体器官移植受者接种SARS-COV-2疫苗后细胞和体液免疫反应的影响

IF 3.3 4区 医学 Q3 IMMUNOLOGY
Manuela Capone , Anna Vanni , Lorenzo Salvati , Giulia Lamacchia , Alessio Mazzoni , Laura Maggi , Lorenzo Cosmi , Francesco Liotta , Paola Romagnani , Luigi Cirillo , Elisa Buti , Vito Terlizzi , Chiara Azzari , Francesco Citera , Federica Barbati , Gian Maria Rossolini , Silvia Bresci , Beatrice Borchi , Annalisa Cavallo , Jessica Mencarini , Francesco Annunziato
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引用次数: 0

摘要

目的:以 mRNA 为基础的新型疫苗已被证明是抗击由 SARS-CoV-2 引起的全球大流行的有力工具,可保护个体(尤其是免疫力低下者)免受 COVID-19 的感染。然而,实体器官移植和不同的免疫抑制药物如何影响疫苗诱导免疫力的发展仍是一个未知数:在这项工作中,我们监测了囊性纤维化肺移植患者(CFT)接种 mRNA SARS-CoV-2 两剂和加强剂量疫苗后的体液和细胞记忆反应,并与未进行肺移植的囊性纤维化患者(CF)和肾移植受者(KT)进行了比较。我们特别研究了移植患者接种 mRNA SARS-CoV-2 疫苗后,免疫抑制方案对 SARS-CoV-2 免疫记忆的影响:结果:我们的研究结果表明,免疫功能低下的移植患者对 SARS-CoV-2 mRNA 疫苗接种表现出微弱的细胞和体液记忆。此外,获得的数据清楚地表明,包括抗代谢药物在内的免疫抑制治疗方案进一步降低了患者在体液和细胞介导水平上对疫苗接种的反应能力。值得注意的是,接受抗代谢药物治疗的患者在接种加强剂量疫苗后,体液和细胞反应也较低:这些结果,即使是在一个小规模的患者群中获得的,也质疑了免疫功能低下的患者是否需要干预措施来改善对 SARS-CoV-2 mRNA 疫苗的反应,如额外的接种或调整免疫抑制疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of antimetabolite regimen on cellular and humoral immune response to SARS-COV-2 vaccination in solid organ transplant recipients

Effect of antimetabolite regimen on cellular and humoral immune response to SARS-COV-2 vaccination in solid organ transplant recipients

Objective

Novel mRNA-based vaccines have been proven to be powerful tools in combating the global pandemic caused by SARS-CoV-2 protecting individuals, especially the immunocompromised, from COVID-19. Still, it remains largely unknown how solid organ transplant and different immunosuppressive medications affect development of vaccine-induced immunity.

Methods

In this work, we monitored humoral and cellular memory responses after mRNA SARS-CoV-2 two-doses and booster doses vaccination in cystic fibrosis lung transplanted patients (CFT) and compared them with both cystic fibrosis patients without lung transplant (CF) and with kidney transplant recipients (KT). In particular, we investigated the effects of immunosuppressive regimens on immune memory to SARS-CoV-2 after mRNA SARS-CoV-2 vaccine in transplanted patients.

Results

Our results showed that immunocompromised transplanted patients displayed a weak cellular and humoral memory to SARS-CoV-2 mRNA vaccination. In addition, obtained data clearly demonstrate that immunosuppressive therapy regimen including antimetabolites, further reduces patients’ ability to respond to vaccination at both humoral and cell-mediated level. Notably, patient treated with antimetabolites showed a lower humoral and cellular response also after a booster dose vaccination.

Conclusion

These results, even if obtained on a small patient's cohort, question whether immunocompromised patients need interventions to improve vaccine SARS-CoV-2 mRNA vaccine response such as additional jab or modulation of immunosuppressive therapy.

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来源期刊
Immunology letters
Immunology letters 医学-免疫学
CiteScore
7.60
自引率
0.00%
发文量
86
审稿时长
44 days
期刊介绍: Immunology Letters provides a vehicle for the speedy publication of experimental papers, (mini)Reviews and Letters to the Editor addressing all aspects of molecular and cellular immunology. The essential criteria for publication will be clarity, experimental soundness and novelty. Results contradictory to current accepted thinking or ideas divergent from actual dogmas will be considered for publication provided that they are based on solid experimental findings. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.
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