Kang Li, Xin Liu, Danfeng Liu, Yuqi Zhi, Chang Dong, Pengrui Sun, Yueming Dong, Hongfang Pan, Yuxiang Zhang, Hong Lei
{"title":"念珠菌感染的临床特征和死亡风险因素","authors":"Kang Li, Xin Liu, Danfeng Liu, Yuqi Zhi, Chang Dong, Pengrui Sun, Yueming Dong, Hongfang Pan, Yuxiang Zhang, Hong Lei","doi":"10.1002/ila2.38","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p><i>Candida auris</i> infections pose a threat to public health, necessitating increased awareness in China. This study aimed to analyze the strains of <i>C</i>. <i>auris</i>, assess the infection status, and investigate clinical characteristics and risk factors for mortality.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A retrospective analysis was conducted on 18 patients with <i>Candida auris</i> infection. We focused on evaluating basic characteristics, strain sources, and antibacterial susceptibility test results. Statistical methods were used to determine clinical features and identify risk factors for death.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The strain type, composition ratio, and specimen source of <i>C</i>. <i>auris</i> were not associated with mortality. Neither the infection index nor the length of hospitalization showed an association with the prognosis. However, significant risk factors for mortality included cerebral infarction, cardiac disease, renal dysfunction, hypoproteinemia, and anemia (all <i>p</i> < 0.05).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Cerebral infarction, cardiac disease, renal dysfunction, hypoproteinemia, and anemia are significant risk factors for death in <i>C</i>. <i>auris</i> infections. These findings indicate the importance of recognizing and addressing these factors in the clinical management of <i>C</i>. <i>auris infection</i>.</p>\n </section>\n </div>","PeriodicalId":100656,"journal":{"name":"iLABMED","volume":"2 2","pages":"79-87"},"PeriodicalIF":0.0000,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ila2.38","citationCount":"0","resultStr":"{\"title\":\"Clinical characteristics and risk factors for mortality in Candida auris infections\",\"authors\":\"Kang Li, Xin Liu, Danfeng Liu, Yuqi Zhi, Chang Dong, Pengrui Sun, Yueming Dong, Hongfang Pan, Yuxiang Zhang, Hong Lei\",\"doi\":\"10.1002/ila2.38\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p><i>Candida auris</i> infections pose a threat to public health, necessitating increased awareness in China. This study aimed to analyze the strains of <i>C</i>. <i>auris</i>, assess the infection status, and investigate clinical characteristics and risk factors for mortality.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A retrospective analysis was conducted on 18 patients with <i>Candida auris</i> infection. We focused on evaluating basic characteristics, strain sources, and antibacterial susceptibility test results. Statistical methods were used to determine clinical features and identify risk factors for death.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The strain type, composition ratio, and specimen source of <i>C</i>. <i>auris</i> were not associated with mortality. Neither the infection index nor the length of hospitalization showed an association with the prognosis. However, significant risk factors for mortality included cerebral infarction, cardiac disease, renal dysfunction, hypoproteinemia, and anemia (all <i>p</i> < 0.05).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Cerebral infarction, cardiac disease, renal dysfunction, hypoproteinemia, and anemia are significant risk factors for death in <i>C</i>. <i>auris</i> infections. These findings indicate the importance of recognizing and addressing these factors in the clinical management of <i>C</i>. <i>auris infection</i>.</p>\\n </section>\\n </div>\",\"PeriodicalId\":100656,\"journal\":{\"name\":\"iLABMED\",\"volume\":\"2 2\",\"pages\":\"79-87\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ila2.38\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"iLABMED\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ila2.38\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"iLABMED","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ila2.38","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Clinical characteristics and risk factors for mortality in Candida auris infections
Background
Candida auris infections pose a threat to public health, necessitating increased awareness in China. This study aimed to analyze the strains of C. auris, assess the infection status, and investigate clinical characteristics and risk factors for mortality.
Methods
A retrospective analysis was conducted on 18 patients with Candida auris infection. We focused on evaluating basic characteristics, strain sources, and antibacterial susceptibility test results. Statistical methods were used to determine clinical features and identify risk factors for death.
Results
The strain type, composition ratio, and specimen source of C. auris were not associated with mortality. Neither the infection index nor the length of hospitalization showed an association with the prognosis. However, significant risk factors for mortality included cerebral infarction, cardiac disease, renal dysfunction, hypoproteinemia, and anemia (all p < 0.05).
Conclusions
Cerebral infarction, cardiac disease, renal dysfunction, hypoproteinemia, and anemia are significant risk factors for death in C. auris infections. These findings indicate the importance of recognizing and addressing these factors in the clinical management of C. auris infection.
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