Wen-Chao Tu , Lin-Fen Ding , Liu-Dong Song , Yong-Jiao Li , Run-Cheng Yan , Yun Wu , Wei-Yang Feng , Xing-De Wu
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引用次数: 0
摘要
从 Caesalpinia minax Hance 的种子中分离并鉴定出八种以前未曾描述过的二萜类化合物，即 Caesamins A-H（1-8）。通过大量光谱数据和 X 射线晶体分析，确定了它们的结构特征。从结构上看，草铵膦 A（1）是第一个具有 C23 碳骨架的决明子类二萜化合物，其中含有一个不寻常的异丙基。草铵膦 F（6）是草铵膦属植物中第一个肉桂烷类二萜化合物。Caesamins B (2) 和 F (6) 对 RAW 264.7 巨噬细胞中 LPS 诱导的一氧化氮产生具有抑制活性，IC50 值分别为 45.67 ± 0.92 和 42.99 ± 0.24 μM，与阳性对照 NG-Monomethyl-L-arginine 的 43.69 ± 2.62 μM 相当。此外，还讨论了分离物的化学分类学意义。
Structurally diverse diterpenoids from the seeds of Caesalpinia minax Hance and their bioactivities
Eight previously undescribed diterpenoids, caesamins A–H (1–8), were separated and identified from the seeds of Caesalpinia minax Hance. Their structures were characterized by extensive spectroscopic data and X-ray crystallographic analysis. Structurally, caesamin A (1) is the first cassane-type diterpenoid with a C23 carbon skeleton containing an unusual isopropyl. Caesamin F (6) represents the first example of cleistanthane diterpenoid from the genus Caesalpinia. Caesamins B (2) and F (6) exhibited inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages with IC50 values of 45.67 ± 0.92 and 42.99 ± 0.24 μM, comparable to positive control 43.69 ± 2.62 μM of NG-Monomethyl-L-arginine. Furthermore, the chemotaxonomic significance of the isolates was discussed.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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