Meta-analysis reveals an association of CAPN10 SNP 44 polymorphism with type 2 diabetes mellitus in Middle Eastern populations

The calpain-10 gene (CAPN10) was the first gene identified to be associated with Type 2 diabetes mellitus. Several polymorphic loci of the calpain-10 gene (CAPN10) have been implicated in the etiology of Type 2 diabetes mellitus. However, the results have been conflicting. Keeping this in view, the present study was aimed at doing a meta-analysis to dig out the association of CAPN SNP 44 (rs2975760) polymorphism with type 2 diabetes mellitus, given that the role of polymorphism at this particular locus is lesser studied than the rest and therefore shrouded in speculations.

Preferred Reporting Items for Systematic Reviews and Meta-analyses PRISMA and the published PROSPERO research protocol was followed for the present study. A total of thirteen studies were included for pooling of data. All statistical analyses were done on R studio (version 4.2.3). The meta-analysis has lead to the conclusion that the genotype ‘CC' has significantly low odds of occurrence in the type 2 diabetes mellitus patients in the Middle Eastern Populations. Therefore, we postulate that the minor allele ‘C' must be playing a protective role against type 2 diabetes mellitus. However, the question of how the ‘CC' genotype must be affecting the incidence of T2DM only the Middle Eastern populations remains to be answered.