i-Motif DNA：识别、形成和细胞功能。

IF 13.6 2区生物学 Q1 GENETICS & HEREDITY

Trends in Genetics Pub Date : 2024-10-01 Epub Date: 2024-06-19 DOI:10.1016/j.tig.2024.05.011

Shentong Tao, Yonghang Run, David Monchaud, Wenli Zhang

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引用次数: 0

摘要

i-motif（iM）是一种由富含胞嘧啶（C）序列折叠而成的四链（四重）DNA 结构。iMs 可在体外多种不同条件下折叠，这为它们在活细胞中的形成铺平了道路。iMs 被认为在各种 DNA 事务中发挥着关键作用，尤其是在基因组稳定性、基因转录、mRNA 翻译、DNA 复制、端粒和中心粒功能以及人类疾病的调控中。我们总结了用于评估 iMs 体外折叠的不同技术，并概述了影响 iMs 在体内形成和稳定性的内部和外部因素。我们描述了 iMs 可能具有的生物学意义，并提出了将其用作生物学靶标的方向。

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i-Motif DNA: identification, formation, and cellular functions.

An i-motif (iM) is a four-stranded (quadruplex) DNA structure that folds from cytosine (C)-rich sequences. iMs can fold under many different conditions in vitro, which paves the way for their formation in living cells. iMs are thought to play key roles in various DNA transactions, notably in the regulation of genome stability, gene transcription, mRNA translation, DNA replication, telomere and centromere functions, and human diseases. We summarize the different techniques used to assess the folding of iMs in vitro and provide an overview of the internal and external factors that affect their formation and stability in vivo. We describe the possible biological relevance of iMs and propose directions towards their use as target in biology.

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来源期刊

Trends in Genetics 生物-遗传学

CiteScore

20.90

自引率

0.90%

发文量

160

审稿时长

6-12 weeks

期刊介绍： Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.