石斛中新发现的具有螺内酯环的菲。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-06-21 DOI:10.1080/10286020.2024.2368831

Natthaphitcha Khunsantiphong, May Thazin Thant, Chattarika Pengdee, Thanarat Salahong, Hnin Ei Ei Khine, Pithi Chanvorachote, Chatchai Chaotham, Boonchoo Sritularak

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引用次数: 0

摘要

石斛烯（1）是一种具有螺内酯环的新菲衍生物，它与 11 种已知化合物（2-12）一起从石斛全株中分离出来。新化合物的结构通过光谱学方法得以阐明，酚类化合物也是首次从石斛中发现。从石斛中分离出的主要化合物 Moscatilin (4) 对 H460 肺癌细胞具有细胞毒性，其 IC50 值为 147.3 ± 0.9 µM，而 C-α-Methoxy 衍生物 loddigesiinol C (7) 没有活性。

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A new phenanthrene with a spirolactone ring from Dendrobium ochreatum.

Dendroochreatene (1), a new phenanthrene derivative with a spirolactone ring, was isolated from the whole Dendrobium ochreatum plant together with 11 known compounds (2-12). The structure of the new compound was elucidated spectroscopically and phenolic compounds were firstly reported from D. ochreatum. Moscatilin (4), major compound isolated from D. ochreatum, was found to be cytotoxic toward H460 lung-cancer cells, with an IC₅₀ value of 147.3 ± 0.9 µM, while loddigesiinol C (7), C-α-methoxy derivative was inactive.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.