Jiahui Du, Shuqing Jin, Ying Zhang, Wei Qiu, Yahui Dong, Yan Liu, Dengke Yin, Ye Yang, Weifang Xu
{"title":"三黄菇提取物对白色念珠菌的体外和体内抑制作用。","authors":"Jiahui Du, Shuqing Jin, Ying Zhang, Wei Qiu, Yahui Dong, Yan Liu, Dengke Yin, Ye Yang, Weifang Xu","doi":"10.1080/17460913.2024.2352269","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> To explore the antifungal potential of Sanghuang mushroom, a traditional Chinese medicine. <b>Materials & methods:</b> The antifungal properties and the potential mechanism of Sanghuang mushroom extracts against <i>Candida albicans</i> were studied <i>in vitro</i> and <i>in vivo</i>. <b>Results:</b> Sanghuang mushroom extracts inhibited the biofilm formation, increased the cell membrane permeability and promoted cell apoptosis of <i>C. albicans in vitro</i>. In a murine model of vulvovaginal candidiasis, Sanghuang mushroom extracts reduced the vaginal fungal load, improved inflammatory cell infiltration and downregulated the expression of TNF-α, IL-1β and IL-6. Untargeted metabolomic analysis suggested the presence of ten antifungal components in Sanghuang mushroom extracts. <b>Conclusion:</b> Sanghuang mushroom extracts showed promise as antifungal agent against candidiasis, with potential therapeutic implications.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318678/pdf/","citationCount":"0","resultStr":"{\"title\":\"<i>In vitro</i> and <i>in vivo</i> inhibitory effects of the Sanghuang mushroom extracts against <i>Candida albicans</i>.\",\"authors\":\"Jiahui Du, Shuqing Jin, Ying Zhang, Wei Qiu, Yahui Dong, Yan Liu, Dengke Yin, Ye Yang, Weifang Xu\",\"doi\":\"10.1080/17460913.2024.2352269\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Aim:</b> To explore the antifungal potential of Sanghuang mushroom, a traditional Chinese medicine. <b>Materials & methods:</b> The antifungal properties and the potential mechanism of Sanghuang mushroom extracts against <i>Candida albicans</i> were studied <i>in vitro</i> and <i>in vivo</i>. <b>Results:</b> Sanghuang mushroom extracts inhibited the biofilm formation, increased the cell membrane permeability and promoted cell apoptosis of <i>C. albicans in vitro</i>. In a murine model of vulvovaginal candidiasis, Sanghuang mushroom extracts reduced the vaginal fungal load, improved inflammatory cell infiltration and downregulated the expression of TNF-α, IL-1β and IL-6. Untargeted metabolomic analysis suggested the presence of ten antifungal components in Sanghuang mushroom extracts. <b>Conclusion:</b> Sanghuang mushroom extracts showed promise as antifungal agent against candidiasis, with potential therapeutic implications.</p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318678/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1080/17460913.2024.2352269\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/21 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/17460913.2024.2352269","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/21 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
In vitro and in vivo inhibitory effects of the Sanghuang mushroom extracts against Candida albicans.
Aim: To explore the antifungal potential of Sanghuang mushroom, a traditional Chinese medicine. Materials & methods: The antifungal properties and the potential mechanism of Sanghuang mushroom extracts against Candida albicans were studied in vitro and in vivo. Results: Sanghuang mushroom extracts inhibited the biofilm formation, increased the cell membrane permeability and promoted cell apoptosis of C. albicans in vitro. In a murine model of vulvovaginal candidiasis, Sanghuang mushroom extracts reduced the vaginal fungal load, improved inflammatory cell infiltration and downregulated the expression of TNF-α, IL-1β and IL-6. Untargeted metabolomic analysis suggested the presence of ten antifungal components in Sanghuang mushroom extracts. Conclusion: Sanghuang mushroom extracts showed promise as antifungal agent against candidiasis, with potential therapeutic implications.
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