用脂肪来源干细胞进行细胞疗法治疗人类跟腱急性断裂的效果。

IF 1.4 4区 医学 Q4 CELL BIOLOGY
Cell and Tissue Banking Pub Date : 2024-09-01 Epub Date: 2024-06-21 DOI:10.1007/s10561-024-10141-4
Maria Helena Costa Vieira, Laynna de Carvalho Schweich-Adami, Rodrigo Juliano Oliveira, Andréia Conceição Milan Brochado Antoniolli-Silva
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引用次数: 0

摘要

本研究旨在评估脂肪源性干细胞(ADSCs)治疗跟腱急性断裂的效果。这是一项横断面研究,共有15名患者参与。患者被随机分为:第一组-断裂;第二组-缝合;第三组-断裂+ADSCs。在 AOFAS 评分中,第 3 组的得分更高,且差异显著。在 ATRS 评分中,第 2 组和第 3 组的得分更高,差异也很明显。至于超声波评分,实验组之间在这一评分方面存在显著差异,但在多重比较试验中,每次比较两个组,可以观察到实验组之间存在显著差异。由此可以得出结论,由于组织再生和功能明显恢复,细胞疗法在这种情况下可能是一种治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of cell therapy with adipose-derived stem cells in the treatment of acute rupture of the Achilles tendon in humans.

Effect of cell therapy with adipose-derived stem cells in the treatment of acute rupture of the Achilles tendon in humans.

The aim of this study was to evaluate the effect of adipose-derived stem cells (ADSCs) in the treatment of acute rupture of the Achilles tendon. It was a cross-sectional study involving 15 patients. Patients were randomly divided: group 1-rupture; group 2-suture; group 3-rupture + ADSCs. In the AOFAS score, the score was higher in group 3 with a significant difference. In the ATRS score, the score was higher in groups 2 and 3, also with a significant difference. As for the ultrasound score, there was a significant difference between the experimental groups in relation to this score, however, in the multiple comparisons test, comparing two groups at a time, it was possible to observe a significant difference of the experimental groups. It can be concluded that cell therapy in this condition may be a treatment option due to tissue regeneration and significant recovery of function.

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来源期刊
Cell and Tissue Banking
Cell and Tissue Banking CELL BIOLOGY-ENGINEERING, BIOMEDICAL
CiteScore
3.10
自引率
13.30%
发文量
68
审稿时长
6-12 weeks
期刊介绍: Cell and Tissue Banking provides a forum for disseminating information to scientists and clinicians involved in the banking and transplantation of cells and tissues. Cell and Tissue Banking is an international, peer-reviewed journal that publishes original papers in the following areas: basic research concerning general aspects of tissue banking such as quality assurance and control of banked cells/tissues, effects of preservation and sterilisation methods on cells/tissues, biotechnology, etc.; clinical applications of banked cells/tissues; standards of practice in procurement, processing, storage and distribution of cells/tissues; ethical issues; medico-legal issues.
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