一名血管免疫母细胞 T 细胞淋巴瘤患者的输尿管间质性肾炎伴星状纤维化。

IF 1 Q4 UROLOGY & NEPHROLOGY

CEN Case Reports Pub Date : 2024-06-20 DOI:10.1007/s13730-024-00901-2

Haruka Fukuda, Mineaki Kitamura, Atsushi Sawase, Tadashi Uramatsu, Hiroshi Yamashita, Hideki Tsushima, Junji Irie, Eisuke Katafuchi, Seiya Kato, Mai Takeuchi, Koichi Ohshima, Toshiyuki Nakayama, Hiroshi Mukae, Tomoya Nishino

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引用次数: 0

摘要

我们报告了一例76岁男性血管免疫母细胞T细胞淋巴瘤（AITL）和伴有支架状纤维化的肾小管间质性肾炎病例。患者表现为淋巴结病、多克隆高丙种球蛋白血症和肾功能障碍，根据淋巴结活检结果被诊断为 AITL。血清 IgG4 水平高度升高。肾活检发现 IgG4 阳性浆细胞和柱状纤维化，但无 AITL 浸润，结果显示为 IgG4 相关性肾病（IgG4-RKD）。在对 AITL 进行 THPCOP 治疗后，患者的肾功能有所改善。虽然在AITL患者中诊断IgG4-RKD是一项挑战，但在该病例中，滤泡辅助T细胞的参与似乎对AITL和肾小管间质病变至关重要。

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Tubulointerstitial nephritis with storiform fibrosis in a patient with angioimmunoblastic T-cell lymphoma.

We present a case of an angioimmunoblastic T-cell lymphoma (AITL) and tubulointerstitial nephritis with storiform fibrosis in a 76-year-old man. The patient exhibited lymphadenopathy, polyclonal hypergammaglobulinemia, and renal dysfunction and was diagnosed with AITL on the basis of lymph node biopsy findings. The serum IgG4 level was highly elevated. Renal biopsy revealed IgG4-positive plasma cells and storiform fibrosis without infiltration of AITL, and the findings indicated IgG4-related kidney disease (IgG4-RKD). Following THPCOP therapy for AITL, the renal function improved. While diagnosing IgG4-RKD in a patient with AITL poses challenges, follicular helper T cell involvement appeared crucial in AITL and renal tubulointerstitial lesions in this case.

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来源期刊

CEN Case Reports UROLOGY & NEPHROLOGY-

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Clinical and Experimental Nephrology (CEN) Case Reports is a peer-reviewed online-only journal, officially published biannually by the Japanese Society of Nephrology (JSN). The journal publishes original case reports in nephrology and related areas. The purpose of CEN Case Reports is to provide clinicians and researchers with a forum in which to disseminate their personal experience to a wide readership and to review interesting cases encountered by colleagues all over the world, from whom contributions are welcomed.