KEAP1 的双重打击

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2024-06-20 DOI:10.1016/j.chembiol.2024.05.014

Jan Gerhartz , Radosław P. Nowak

引用次数: 0

摘要

在本期《细胞化学生物学》（Cell Chemical Biology）杂志上，Lu 等人1 报道了一种双价 KEAP1 抑制剂（biKEAP1）的发现，与之前报道的单价 KEAP1 抑制剂相比，它能更快地激活 NRF2。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A double whammy for KEAP1

In this issue of Cell Chemical Biology, Lu et al.¹ report the discovery of a bivalent KEAP1 inhibitor (biKEAP1), which more rapidly activates NRF2 compared to previously reported monovalent KEAP1 inhibitors. biKEAP1suppresses acute inflammation in animal models.

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.