防止 MMP23 介导的荚膜细胞 RARRES1 分裂：阻止慢性肾病进展的新策略？

IF 14.8 1区医学 Q1 UROLOGY & NEPHROLOGY

Kidney international Pub Date : 2024-06-19 DOI:10.1016/j.kint.2024.05.004

Paulina X. Medina Rangel , Shuta Ishibe

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引用次数: 0

摘要

肾小球问题和受影响的荚膜细胞是 80% 慢性肾病的根源。因此，有必要深入了解这一领域，以阻止肾脏逐渐受损。在这项研究中，作者调查了荚膜细胞裂解的可溶性视黄酸受体应答蛋白-1对荚膜细胞和近端肾小管细胞的有害影响，并确定基质金属蛋白酶23是负责裂解视黄酸受体应答蛋白-1的酶。这些发现为慢性肾脏病的进展提供了新的见解，并提出了创新的治疗途径。

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Preventing MMP23-mediated cleavage of podocyte RARRES1: a novel strategy to halt chronic kidney disease progression?

Glomerular issues and affected podocytes are at the origin of 80% of chronic kidney disease cases. Thus, acquiring a deeper understanding in this domain is necessary to halt progressive kidney damage. In this study, the authors investigated the harmful impact of podocyte-cleaved soluble retinoic acid receptor responder protein-1 on podocytes and proximal tubular cells and identified matrix metalloprotease 23 as the enzyme responsible for cleaving retinoic acid receptor responder protein-1. These findings provide new insights into chronic kidney disease progression, suggesting innovative treatment avenues.

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.