经过 40 年对德尔表型的研究，输血实践发生了变化。

IF 2.5 3区医学 Q2 HEMATOLOGY

Transfusion Pub Date : 2024-07-01 Epub Date: 2024-06-20 DOI:10.1111/trf.17913

Willy Albert Flegel, Kshitij Srivastava

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引用次数: 0

摘要

在常规血清学检查中，抗-D 不能凝集任何 Del 表型的红细胞。许多血清学中 D 型阴性的东亚血统个体都携带 Del 表型。几乎所有这些人都携带一种独特的 DEL 变异体，被称为亚洲型 DEL，即 RHD*01EL.01、RHD*DEL1、RHD:c.1227G>A，以前称为 RHD(K409K)。临床证据有力地表明，亚洲型 DEL 患者可以安全地输注 RhD 阳性血液，并且在怀孕期间不需要进行抗 D 预防。

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40 years of researching the Del phenotype results in a change of transfusion practice.

Anti-D cannot agglutinate red cells of any Del phenotype in routine serology. Many individuals with East Asian ancestry who type D-negative in serology harbor a Del phenotype. Almost all such individuals carry one distinct DEL variant, dubbed Asian-type DEL, known as RHD*01EL.01, RHD*DEL1, RHD:c.1227G>A, formerly known as RHD(K409K). Clinical evidence strongly suggests that Asian-type DEL individuals can safely be transfused with RhD-positive blood and do not need anti-D prophylaxis in pregnancy.

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来源期刊

Transfusion 医学-血液学

CiteScore

4.70

自引率

20.70%

发文量

426

审稿时长

1 months

期刊介绍： TRANSFUSION is the foremost publication in the world for new information regarding transfusion medicine. Written by and for members of AABB and other health-care workers, TRANSFUSION reports on the latest technical advances, discusses opposing viewpoints regarding controversial issues, and presents key conference proceedings. In addition to blood banking and transfusion medicine topics, TRANSFUSION presents submissions concerning patient blood management, tissue transplantation and hematopoietic, cellular, and gene therapies.