与全氟辛烷磺酸暴露和孕妇围产期/产后抑郁相关的代谢紊乱:中间相遇范围审查》。

IF 7.4 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Current Environmental Health Reports Pub Date : 2024-09-01 Epub Date: 2024-06-19 DOI:10.1007/s40572-024-00451-w
Himal Suthar, Roselyn B Tanghal, Lida Chatzi, Jesse A Goodrich, Rachel Morello-Frosch, Max Aung
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引用次数: 0

摘要

审查目的:全球每 10 名妇女中至少有 1 人在围产期或产前出现抑郁,对母婴健康造成长期影响。与此同时,越来越多的证据表明,孕产妇接触全氟和多氟烷基物质(PFAS)与不良妊娠结局有关。我们回顾了研究全氟辛烷磺酸暴露与孕产妇代谢组紊乱之间关系以及孕产妇代谢组与围产期/产前抑郁之间关系的大量证据。通过这些研究,我们试图探索围产期代谢组作为连接全氟辛烷磺酸暴露与围产期/围产期抑郁症的潜在中介途径的现有证据:很少有研究既研究了孕妇接触 PFAS 的代谢组学,也研究了围产期/围产期抑郁症的代谢组学,更不用说同时研究这两者的研究了。在已审查的研究(N = 11)中,大部分是横断面研究,研究地点不在美国,研究对象基本相同。我们的综述在围产期代谢组中发现了 23 条与全氟辛烷磺酸暴露和围产期/产前抑郁共同相关的代谢途径。未来的研究在探索因暴露于 PFAS 而导致围产期/产前抑郁风险的生化机制时,可考虑我们的综述结果,以脂肪酸代谢、丙氨酸代谢、谷氨酸代谢和酪氨酸代谢为重点进行文献衍生假设检验。我们建议研究人员还利用异质人群、纵向研究设计和中介方法来阐明将 PFAS 暴露与围产期/产前抑郁症联系起来的关键途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolic Perturbations Associated with both PFAS Exposure and Perinatal/Antenatal Depression in Pregnant Individuals: A Meet-in-the-Middle Scoping Review.

Purpose of review: Depression during the perinatal or antenatal period affects at least 1 in 10 women worldwide, with long term health implications for the mother and child. Concurrently, there is increasing evidence associating maternal exposure to per- and poly-fluoroalkyl substances (PFAS) to adverse pregnancy outcomes. We reviewed the body of evidence examining both the associations between PFAS exposure and perturbations in the maternal metabolome, and the associations between the maternal metabolome and perinatal/antenatal depression. Through this, we sought to explore existing evidence of the perinatal metabolome as a potential mediation pathway linking PFAS exposure and perinatal/antenatal depression.

Recent findings: There are few studies examining the metabolomics of PFAS exposure-specifically in pregnant women-and the metabolomics of perinatal/antenatal depression, let alone studies examining both simultaneously. Of the studies reviewed (N = 11), the majority were cross sectional, based outside of the US, and conducted on largely homogenous populations. Our review identified 23 metabolic pathways in the perinatal metabolome common to both PFAS exposure and perinatal/antenatal depression. Future studies may consider findings from our review to conduct literature-derived hypothesis testing focusing on fatty acid metabolism, alanine metabolism, glutamate metabolism, and tyrosine metabolism when exploring the biochemical mechanisms conferring the risk of perinatal/antenatal depression due to PFAS exposure. We recommend that researchers also utilize heterogenous populations, longitudinal study designs, and mediation approaches to elucidate key pathways linking PFAS exposures to perinatal/antenatal depression.

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来源期刊
CiteScore
13.60
自引率
1.30%
发文量
47
期刊介绍: Current Environmental Health Reports provides up-to-date expert reviews in environmental health. The goal is to evaluate and synthesize original research in all disciplines relevant for environmental health sciences, including basic research, clinical research, epidemiology, and environmental policy.
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