及时输注白蛋白可提高肝硬化和自发性细菌性腹膜炎患者的资源利用率

IF 2.6 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BioMed Research International Pub Date : 2024-06-08 eCollection Date: 2024-01-01 DOI:10.1155/2024/6673823
W Ray Kim, Karthik Raghunathan, Greg S Martin, E Anne Davis, Navreet Sandhu Sindhwani, Santosh Telang, Kunal Lodaya
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引用次数: 0

摘要

自发性细菌性腹膜炎是肝硬化的一种危及生命的并发症,会增加医疗资源的使用。尽管白蛋白能有效提高自发性细菌性腹膜炎肝硬化患者的生存率,但白蛋白给药时机对医院资源利用率的影响及其最佳时机尚不明确。我们开展了一项回顾性研究,以评估白蛋白给药时机对需要液体复苏的肝硬化合并自发性细菌性腹膜炎患者的住院时间和住院总费用的影响。该研究采用了 Cerner Health Facts® 数据中的去标识化数据。研究纳入了2009年1月1日至2018年4月30日期间诊断为肝硬化和SBP的成人住院患者,这些患者接受了≥1种抗生素和液体复苏,并根据白蛋白给药时间进行了分层:入院后≤24小时("及时给白蛋白")或入院后>24小时或未给白蛋白("非及时给白蛋白")。我们使用 Kaplan-Meier 曲线和对数秩检验来评估白蛋白给药时间与出院时间之间的关系,并使用广义线性模型来检验白蛋白给药时间与住院总费用之间的关系。我们确定了 1308 例住院病例,其中 301 例包含有效的费用数据。及时白蛋白组的中位出院时间为 6.95 天,而非及时白蛋白组为 7.78 天(P = 0.02)。成本模型显示,及时接受白蛋白治疗的患者比未及时接受白蛋白治疗组患者的成本低 16%(p = 0.027)。及时给予白蛋白和抗生素治疗可缩短住院时间并降低费用,从而减少需要液体复苏的肝硬化和自发性细菌性腹膜炎患者的医院资源使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Timely Albumin Infusion May Improve Resource Utilization in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis.

Spontaneous bacterial peritonitis is a life-threatening complication of cirrhosis that can increase healthcare utilization. The impact of albumin administration timing on hospital resource utilization and its optimal timing is unclear, despite its efficacy in improving survival for cirrhosis patients with spontaneous bacterial peritonitis. A retrospective study was conducted to evaluate the influence of the timing of albumin administration on the length of stay and total hospital cost for patients with cirrhosis and spontaneous bacterial peritonitis who require fluid resuscitation. The study utilized de-identified data from Cerner Health Facts® data. Adult inpatients with a diagnosis of cirrhosis and SBP receiving ≥1 antibiotic and fluid resuscitation between January 1, 2009, and April 30, 2018, were included and stratified by albumin administration timing: ≤24 hours from hospital admission ("timely albumin") or >24 hours of admission or no albumin ("non-timely albumin"). We used a Kaplan-Meier curve with log-rank test to evaluate the association between timing of albumin administration and time to hospital discharge and a generalized linear model to examine the association between albumin timing and total hospital costs. We identified 1,308 hospitalizations, of which 301 contained valid cost data. The timely albumin group had a median time to discharge of 6.95 days compared to 7.78 days in the non-timely group (p = 0.02). Cost model showed that receiving timely albumin incurred 16% lower costs (p = 0.027) than patients in the non-timely albumin group. Timely albumin administration with an antibiotic regimen may shorten the length of stay and lower costs, thereby reducing hospital resource utilization in patients with cirrhosis and spontaneous bacterial peritonitis requiring fluid resuscitation.

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来源期刊
BioMed Research International
BioMed Research International BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
6.70
自引率
0.00%
发文量
1942
审稿时长
19 weeks
期刊介绍: BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
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