封底：用于应对抗生素耐药菌感染的核壳结构沸石咪唑酸盐框架@阳离子抗菌剂模板化二氧化硅纳米复合材料

IF 13.9 Q1 CHEMISTRY, MULTIDISCIPLINARY

Aggregate (Hoboken, N.J.) Pub Date : 2024-06-18 DOI:10.1002/agt2.618

Qihui Kan, Yaping Song, Yining Yao, Jun Zhang, He Xian, Dan Cheng, Yue Wang, Liang Mao, Meiyan Wang, Chengzhong Yu

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引用次数: 0

摘要

本研究设计了一种抗耐药菌核壳结构，以抗菌沸石咪唑酸框架-8（ZIF-8）为核，以杀菌苯扎氯铵（BAC）模板化粗糙表面介质结构二氧化硅纳米复合材料（RMSN）为壳。由此产生的 ZIF-8@RMSN 纳米复合材料可持续释放 BAC 和锌离子，从而增强了对耐药性细菌的抗菌和消除生物膜的特性。此外，ZIF-8@RMSN 改性抗菌创可贴在体外和体内都具有出色的抗耐药菌感染特性 (e523)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Back Cover: A core–shell-structured zeolitic imidazolate framework@cationic antimicrobial agent templated silica nanocomposite for tackling antibiotic resistant bacteria infection

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Back Cover: A core–shell-structured zeolitic imidazolate framework@cationic antimicrobial agent templated silica nanocomposite for tackling antibiotic resistant bacteria infection

An anti-drug-resistant bacteria core-shell structure is designed, containing antibacterial zeolitic imidazolate framework-8 (ZIF-8) as the core and bactericidal benzalkonium chloride (BAC) templated rough-surface mesostructured silica nanocomposite (RMSN) as the shell. The resultant ZIF-8@RMSN nanocomposite exhibits sustained release of BAC and zinc ions, leading to enhanced antibacterial and biofilm elimination properties against drug-resistant bacterial. In addition, ZIF-8@RMSN modified antibacterial band-aid possesses excellent anti-drug-resistant bacterial infection properties both in vitro and in vivo (e523).

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来源期刊

Aggregate (Hoboken, N.J.)

CiteScore

17.40

自引率

0.00%

发文量

审稿时长

7 weeks