{"title":"学龄前儿童尿碘浓度与 4 岁和 6 岁时的认知发展--希腊克里特岛雷亚母子队列","authors":"Mariza Kampouri , Katerina Margetaki , Katerina Koutra , Andriani Kyriklaki , Vasiliki Daraki , Theano Roumeliotaki , Vicky Bempi , Marina Vafeiadi , Manolis Kogevinas , Lida Chatzi , Maria Kippler","doi":"10.1016/j.jtemb.2024.127486","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Evidence regarding child iodine intake and neurodevelopment is scarce.</p></div><div><h3>Methods</h3><p>We aimed to assess the impact of child iodine intake at 4 years of age on cognitive and motor development at 4 and 6 years among 304 children from the Rhea cohort on Crete, Greece. Child iodine intake was assessed via urinary iodine concentrations (UIC) measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and adjusted for specific gravity. Child cognitive and motor development was assessed using the <em>McCarthy Scales of Children's Abilities (MSCA)</em> at 4 years of age and <em>Raven’s Coloured Progressive Matrices</em> (<em>RCPM</em>), <em>Finger Tapping Test</em> (<em>FTT</em>)<em>,</em> and <em>Trail Making Test</em> (<em>TMT</em>) at 6 years. Associations were explored using multivariable-adjusted linear regression analyses with UIC categorized according to WHO criteria [insufficient intake <100 µg/L, adequate 100–299 µg/L (reference group), excessive ≥300 µg/L].</p></div><div><h3>Results</h3><p>The children’s median UIC was 249 µg/L (25–75th percentile: 181–344 μg/L). Children with UIC <100 μg/L had lower scores in the motor scale at 4 years (<em>MSCA-motor scale</em>: B=-10.3; 95 %CI −19.9, −0.6; n=10) and in intelligence at 6 years (<em>RCPM-total score:</em> B=-3.6, 95 %CI −6.8, −0.5; n=9) than children in the reference group. No associations were found with the general cognitive scale at 4 years or with <em>TMT</em> and <em>FTT</em> scales at 6 years. Children with UIC ≥300 μg/L had lower cognitive scores both at 4 (<em>MSCA</em>; B= −3.5; 95 %CI −6.9, −0.1; n =101) and 6 years of age (<em>RCPM-total score</em>; B= −1.2; 95 %CI −2.3, −0.0; n =98) than children in the reference group. No associations were observed with the motor scale at 4 years or with <em>TMT</em> and <em>FTT</em> scales at 6 years.</p></div><div><h3>Conclusion</h3><p>Our findings indicate that both low and excessive iodine intake at preschool age may adversely affect child cognitive abilities. Additionally, low iodine intake may also impact motor abilities.</p></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"85 ","pages":"Article 127486"},"PeriodicalIF":3.6000,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Urinary iodine concentrations in preschoolers and cognitive development at 4 and 6 years of age, the Rhea mother-child cohort on Crete, Greece\",\"authors\":\"Mariza Kampouri , Katerina Margetaki , Katerina Koutra , Andriani Kyriklaki , Vasiliki Daraki , Theano Roumeliotaki , Vicky Bempi , Marina Vafeiadi , Manolis Kogevinas , Lida Chatzi , Maria Kippler\",\"doi\":\"10.1016/j.jtemb.2024.127486\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Evidence regarding child iodine intake and neurodevelopment is scarce.</p></div><div><h3>Methods</h3><p>We aimed to assess the impact of child iodine intake at 4 years of age on cognitive and motor development at 4 and 6 years among 304 children from the Rhea cohort on Crete, Greece. Child iodine intake was assessed via urinary iodine concentrations (UIC) measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and adjusted for specific gravity. Child cognitive and motor development was assessed using the <em>McCarthy Scales of Children's Abilities (MSCA)</em> at 4 years of age and <em>Raven’s Coloured Progressive Matrices</em> (<em>RCPM</em>), <em>Finger Tapping Test</em> (<em>FTT</em>)<em>,</em> and <em>Trail Making Test</em> (<em>TMT</em>) at 6 years. Associations were explored using multivariable-adjusted linear regression analyses with UIC categorized according to WHO criteria [insufficient intake <100 µg/L, adequate 100–299 µg/L (reference group), excessive ≥300 µg/L].</p></div><div><h3>Results</h3><p>The children’s median UIC was 249 µg/L (25–75th percentile: 181–344 μg/L). Children with UIC <100 μg/L had lower scores in the motor scale at 4 years (<em>MSCA-motor scale</em>: B=-10.3; 95 %CI −19.9, −0.6; n=10) and in intelligence at 6 years (<em>RCPM-total score:</em> B=-3.6, 95 %CI −6.8, −0.5; n=9) than children in the reference group. No associations were found with the general cognitive scale at 4 years or with <em>TMT</em> and <em>FTT</em> scales at 6 years. Children with UIC ≥300 μg/L had lower cognitive scores both at 4 (<em>MSCA</em>; B= −3.5; 95 %CI −6.9, −0.1; n =101) and 6 years of age (<em>RCPM-total score</em>; B= −1.2; 95 %CI −2.3, −0.0; n =98) than children in the reference group. No associations were observed with the motor scale at 4 years or with <em>TMT</em> and <em>FTT</em> scales at 6 years.</p></div><div><h3>Conclusion</h3><p>Our findings indicate that both low and excessive iodine intake at preschool age may adversely affect child cognitive abilities. Additionally, low iodine intake may also impact motor abilities.</p></div>\",\"PeriodicalId\":49970,\"journal\":{\"name\":\"Journal of Trace Elements in Medicine and Biology\",\"volume\":\"85 \",\"pages\":\"Article 127486\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2024-06-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Trace Elements in Medicine and Biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0946672X24001068\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Trace Elements in Medicine and Biology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0946672X24001068","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Urinary iodine concentrations in preschoolers and cognitive development at 4 and 6 years of age, the Rhea mother-child cohort on Crete, Greece
Background
Evidence regarding child iodine intake and neurodevelopment is scarce.
Methods
We aimed to assess the impact of child iodine intake at 4 years of age on cognitive and motor development at 4 and 6 years among 304 children from the Rhea cohort on Crete, Greece. Child iodine intake was assessed via urinary iodine concentrations (UIC) measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and adjusted for specific gravity. Child cognitive and motor development was assessed using the McCarthy Scales of Children's Abilities (MSCA) at 4 years of age and Raven’s Coloured Progressive Matrices (RCPM), Finger Tapping Test (FTT), and Trail Making Test (TMT) at 6 years. Associations were explored using multivariable-adjusted linear regression analyses with UIC categorized according to WHO criteria [insufficient intake <100 µg/L, adequate 100–299 µg/L (reference group), excessive ≥300 µg/L].
Results
The children’s median UIC was 249 µg/L (25–75th percentile: 181–344 μg/L). Children with UIC <100 μg/L had lower scores in the motor scale at 4 years (MSCA-motor scale: B=-10.3; 95 %CI −19.9, −0.6; n=10) and in intelligence at 6 years (RCPM-total score: B=-3.6, 95 %CI −6.8, −0.5; n=9) than children in the reference group. No associations were found with the general cognitive scale at 4 years or with TMT and FTT scales at 6 years. Children with UIC ≥300 μg/L had lower cognitive scores both at 4 (MSCA; B= −3.5; 95 %CI −6.9, −0.1; n =101) and 6 years of age (RCPM-total score; B= −1.2; 95 %CI −2.3, −0.0; n =98) than children in the reference group. No associations were observed with the motor scale at 4 years or with TMT and FTT scales at 6 years.
Conclusion
Our findings indicate that both low and excessive iodine intake at preschool age may adversely affect child cognitive abilities. Additionally, low iodine intake may also impact motor abilities.
期刊介绍:
The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods.
Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.