{"title":"用于等离子体光热疗法的纳米粒子嵌入肿瘤模型各向异性因子的测量。","authors":"Vikas, Raj Kumar, Sanjeev Soni","doi":"10.1002/jbio.202400007","DOIUrl":null,"url":null,"abstract":"<p>Measurement of anisotropy factor (<i>g</i>) in the presence of nanoparticles (NPs) is important for understanding light distribution for plasmonic photothermal cancer therapeutics. Here, anisotropy factor is investigated through bilayer phantoms (epidermal and dermal) of various thicknesses incorporated with gold nanorods (GNRs) concentrations of 10–40 μg/mL by using in-house developed goniometric setup. Results show that 10 μg/mL GNRs in the phantom increase <i>g</i> by ~50% (<i>g</i> = 0.9471) w.r.t. phantom without NPs. Higher concentrations (40 μg/mL) of GNRs decrease <i>g</i> by ~43% (<i>g</i> = 0.5341) w.r.t. phantom with 10 μg/mL GNRs. For 40 μg/mL GNRs phantom, the anisotropy factor reduces by 47% for phantom thickness from 600 to 1800 μm. Anisotropy factor of GNR embedded phantom increased by 44% by using glycerol (10%–40%). Incorporation of NPs in a tumor significantly affects <i>g</i>, a major parameter for light distribution. These measurements provide insights for light scattering based on nanoparticle doses for plasmonic photothermal therapeutics.</p>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"17 8","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Measurement of anisotropy factor of nanoparticle embedded tumor phantoms for plasmonic photothermal therapeutics\",\"authors\":\"Vikas, Raj Kumar, Sanjeev Soni\",\"doi\":\"10.1002/jbio.202400007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Measurement of anisotropy factor (<i>g</i>) in the presence of nanoparticles (NPs) is important for understanding light distribution for plasmonic photothermal cancer therapeutics. Here, anisotropy factor is investigated through bilayer phantoms (epidermal and dermal) of various thicknesses incorporated with gold nanorods (GNRs) concentrations of 10–40 μg/mL by using in-house developed goniometric setup. Results show that 10 μg/mL GNRs in the phantom increase <i>g</i> by ~50% (<i>g</i> = 0.9471) w.r.t. phantom without NPs. Higher concentrations (40 μg/mL) of GNRs decrease <i>g</i> by ~43% (<i>g</i> = 0.5341) w.r.t. phantom with 10 μg/mL GNRs. For 40 μg/mL GNRs phantom, the anisotropy factor reduces by 47% for phantom thickness from 600 to 1800 μm. Anisotropy factor of GNR embedded phantom increased by 44% by using glycerol (10%–40%). Incorporation of NPs in a tumor significantly affects <i>g</i>, a major parameter for light distribution. These measurements provide insights for light scattering based on nanoparticle doses for plasmonic photothermal therapeutics.</p>\",\"PeriodicalId\":184,\"journal\":{\"name\":\"Journal of Biophotonics\",\"volume\":\"17 8\",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biophotonics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jbio.202400007\",\"RegionNum\":3,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biophotonics","FirstCategoryId":"101","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbio.202400007","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
Measurement of anisotropy factor of nanoparticle embedded tumor phantoms for plasmonic photothermal therapeutics
Measurement of anisotropy factor (g) in the presence of nanoparticles (NPs) is important for understanding light distribution for plasmonic photothermal cancer therapeutics. Here, anisotropy factor is investigated through bilayer phantoms (epidermal and dermal) of various thicknesses incorporated with gold nanorods (GNRs) concentrations of 10–40 μg/mL by using in-house developed goniometric setup. Results show that 10 μg/mL GNRs in the phantom increase g by ~50% (g = 0.9471) w.r.t. phantom without NPs. Higher concentrations (40 μg/mL) of GNRs decrease g by ~43% (g = 0.5341) w.r.t. phantom with 10 μg/mL GNRs. For 40 μg/mL GNRs phantom, the anisotropy factor reduces by 47% for phantom thickness from 600 to 1800 μm. Anisotropy factor of GNR embedded phantom increased by 44% by using glycerol (10%–40%). Incorporation of NPs in a tumor significantly affects g, a major parameter for light distribution. These measurements provide insights for light scattering based on nanoparticle doses for plasmonic photothermal therapeutics.
期刊介绍:
The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.