用于等离子体光热疗法的纳米粒子嵌入肿瘤模型各向异性因子的测量。

IF 2 3区 物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS
Vikas, Raj Kumar, Sanjeev Soni
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引用次数: 0

摘要

测量纳米粒子(NPs)存在时的各向异性因子(g)对于了解等离子体光热治疗癌症的光分布非常重要。在此,我们利用自行开发的测角装置,通过加入浓度为 10-40 μg/mL 的金纳米棒(GNRs)的不同厚度双层模型(表皮和真皮)研究了各向异性因子。结果显示,与不含 NPs 的模型相比,模型中 10 μg/mL 的 GNRs 使 g 值增加了约 50%(g = 0.9471)。较高浓度(40 μg/mL)的 GNRs 会使 G 值相对于含有 10 μg/mL GNRs 的模型降低约 43%(g = 0.5341)。对于 40 μg/mL GNRs 的模型,模型厚度从 600 μm 到 1800 μm 时,各向异性系数降低了 47%。通过使用甘油(10%-40%),GNR 嵌入模型的各向异性系数增加了 44%。肿瘤中 NPs 的掺入会显著影响光分布的主要参数 g。这些测量结果为基于纳米粒子剂量的等离子光热疗法的光散射提供了启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Measurement of anisotropy factor of nanoparticle embedded tumor phantoms for plasmonic photothermal therapeutics

Measurement of anisotropy factor of nanoparticle embedded tumor phantoms for plasmonic photothermal therapeutics

Measurement of anisotropy factor (g) in the presence of nanoparticles (NPs) is important for understanding light distribution for plasmonic photothermal cancer therapeutics. Here, anisotropy factor is investigated through bilayer phantoms (epidermal and dermal) of various thicknesses incorporated with gold nanorods (GNRs) concentrations of 10–40 μg/mL by using in-house developed goniometric setup. Results show that 10 μg/mL GNRs in the phantom increase g by ~50% (g = 0.9471) w.r.t. phantom without NPs. Higher concentrations (40 μg/mL) of GNRs decrease g by ~43% (g = 0.5341) w.r.t. phantom with 10 μg/mL GNRs. For 40 μg/mL GNRs phantom, the anisotropy factor reduces by 47% for phantom thickness from 600 to 1800 μm. Anisotropy factor of GNR embedded phantom increased by 44% by using glycerol (10%–40%). Incorporation of NPs in a tumor significantly affects g, a major parameter for light distribution. These measurements provide insights for light scattering based on nanoparticle doses for plasmonic photothermal therapeutics.

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来源期刊
Journal of Biophotonics
Journal of Biophotonics 生物-生化研究方法
CiteScore
5.70
自引率
7.10%
发文量
248
审稿时长
1 months
期刊介绍: The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
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