APOE基因型、海马体积和认知储备可预测认知训练对无痴呆症老年人的改善:一项随机对照试验。

IF 1.7 4区 心理学 Q3 PSYCHOLOGY, EXPERIMENTAL
Cognitive Processing Pub Date : 2024-11-01 Epub Date: 2024-06-19 DOI:10.1007/s10339-024-01202-3
Pedro Montejo Carrasco, Mercedes Montenegro-Peña, David Prada Crespo, Inmaculada Rodríguez Rojo, Ana Barabash Bustelo, Borja Montejo Rubio, Alberto Marcos Dolado, Fernando Maestú Unturbe, María Luisa Delgado Losada
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引用次数: 0

摘要

认知训练(CT)计划旨在提高认知能力并阻止其下降。因此,确定能从这些干预措施中受益的个体特征至关重要。我们的目标是评估认知储备(CR)、APOE基因型(e4携带者/非携带者)和/或海马体积是否能预测CT项目的效果。参与者为无痴呆症的老年人(n = 226),随机分为实验组和对照组。评估包括神经心理学方案和有关颅内总体积、灰质、左/右海马体积、APOE基因型和认知储备(CR)的其他数据。干预措施包括多因素 CT(30 次,每次 90 分钟),并在培训前后(6 个月时)进行评估;对照组只需参加中心的常规活动。主要结果指标是认知能力的变化和变化的预测因素。结果显示,左侧海马体积较大的非 APOE-e4 携带者(79.1%)在语义语言流畅性方面取得了更好的进步(R2 = 0.19)。CR较大且灰质体积较大的受试者在处理速度方面有更好的提高(R2 = 0.18)。年龄与执行功能的改善相关,年龄越大,改善越小(R2 = 0.07)。左侧海马体积较大的受试者在一般认知能力方面的提高更为显著(R2 = 0.087)。总之,除了程序本身,CT 的有效性还取决于年龄、基因型和脑容量等生物因素以及 CR。因此,要想通过 CT 取得更好的效果,必须考虑参与者的不同特点,包括遗传因素:试验于 2020 年 1 月 29 日进行了回顾性注册(ClinicalTrials.gov -NCT04245579)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

APOE genotype, hippocampal volume, and cognitive reserve predict improvement by cognitive training in older adults without dementia: a randomized controlled trial.

APOE genotype, hippocampal volume, and cognitive reserve predict improvement by cognitive training in older adults without dementia: a randomized controlled trial.

Cognitive training (CT) programs aim to improve cognitive performance and impede its decline. Thus, defining the characteristics of individuals who can benefit from these interventions is essential. Our objectives were to assess if the cognitive reserve (CR), APOE genotype (e4 carriers/non-carriers) and/or hippocampal volume might predict the effectiveness of a CT program. Participants were older adults without dementia (n = 226), randomized into parallel experimental and control groups. The assessment consisted of a neuropsychological protocol and additional data regarding total intracranial, gray matter, left/right hippocampus volume; APOE genotype; and Cognitive Reserve (CR). The intervention involved multifactorial CT (30 sessions, 90 min each), with an evaluation pre- and post-training (at six months); the control group simply following the center's routine activities. The primary outcome measures were the change in cognitive performance and the predictors of change. The results show that APOE-e4 non-carriers (79.1%) with a larger left hippocampal volume achieved better gains in semantic verbal fluency (R2 = .19). Subjects with a larger CR and a greater gray matter volume better improved their processing speed (R2 = .18). Age was correlated with the improvement in executive functions, such that older age predicts less improvement (R2 = .07). Subjects with a larger left hippocampal volume achieved more significant gains in general cognitive performance (R2 = .087). In conclusion, besides the program itself, the effectiveness of CT depends on age, biological factors like genotype and brain volume, and CR. Thus, to achieve better results through a CT, it is essential to consider the different characteristics of the participants, including genetic factors.Trial registration: Trial retrospectively registered on January 29th, 2020-(ClinicalTrials.gov -NCT04245579).

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来源期刊
Cognitive Processing
Cognitive Processing PSYCHOLOGY, EXPERIMENTAL-
CiteScore
3.10
自引率
5.90%
发文量
44
期刊介绍: Cognitive Processing - International Quarterly of Cognitive Science is a peer-reviewed international journal that publishes innovative contributions in the multidisciplinary field of cognitive science.  Its main purpose is to stimulate research and scientific interaction through communication between specialists in different fields on topics of common interest and to promote an interdisciplinary understanding of the diverse topics in contemporary cognitive science. Cognitive Processing is articulated in the following sections:Cognitive DevelopmentCognitive Models of Risk and Decision MakingCognitive NeuroscienceCognitive PsychologyComputational Cognitive SciencesPhilosophy of MindNeuroimaging and Electrophysiological MethodsPsycholinguistics and Computational linguisticsQuantitative Psychology and Formal Theories in Cognitive ScienceSocial Cognition and Cognitive Science of Culture
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