与吸烟相关的气管内毛发生长:气管并发症病例报告。

IF 1 Q3 MEDICINE, GENERAL & INTERNAL
Paul Thöne, Roland Kropfmüller, Daniela Gompelmann, Bernd Lamprecht, David Lang
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引用次数: 0

摘要

背景:一名 52 岁的男性患者在气管造口手术闭合 26 年后出现慢性咳嗽和持续气管刺激症状,并得到自体耳软骨移植和皮肤移植的支持。在最初的临床表现中,患者是一名活跃的吸烟者,累计吸烟量达 31 包年。病例报告 支气管镜检查发现气管内毛发生长,移植部位出现局部炎症。患者接受了初步的抗炎、抗霉菌和抗菌治疗,随后进行了内窥镜结构重塑。患者多次复发,症状相似,表现为孤立的毛发生长,无炎症。医生建议每年进行一次内窥镜结构重塑治疗,患者感觉治疗效果非常好。通过氩等离子激光凝固术和戒烟后,反复生长的毛发最终被终止。我们推测,毛发生长是由患者吸烟引发的。结论 气管内毛发生长是自体移植物支持气管重建的潜在并发症。最初使用抗菌消炎药物并结合内窥镜重组,可以控制活跃的炎症;氩等离子激光凝固术的应用最终阻止了毛发生长。吸烟与呼吸道上皮的分子信号通路上调有关,这些通路可刺激毛囊,如声波刺猬蛋白、WNT-1/ß-catenin 和表皮生长因子受体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Smoking-Associated Endotracheal Hair Growth: A Case Report on Tracheal Complications.

BACKGROUND A 52-year-old male patient presented with symptoms of chronic cough and persistent tracheal irritation 26 years after surgical closure of a tracheostoma, supported by an autologous auricular cartilage graft and cutaneous transplant. At the initial clinical presentation, the patient was an active smoker, with a cumulative dose of 31 pack years. CASE REPORT Bronchoscopy revealed endotracheal hair growth and local inflammation at the graft site. Initial anti-inflammatory, antimycotic, and antibacterial therapy was administered, followed by endoscopic structure remodeling. There were multiple recurrences with similar symptoms, showing isolated hair growth, without inflammation. Annual endoscopic restructuring sessions were indicated, and the patient experienced them as highly relieving. Recurrent hair growth was finally terminated by argon plasma laser-coagulation and after smoking cessation. We hypothesize that the onset of hair growth was triggered by the patient's cigarette smoking. CONCLUSIONS Endotracheal hair growth is a potential complication of autograft-supported tracheal restructuring. The initial administration of antimicrobial and anti-inflammatory medication, combined with endoscopic restructuring, could have contained the active inflammation; the application of argon plasma laser-coagulation finally stopped the hair growth. Smoking is associated with the upregulation of molecular signaling pathways in the respiratory epithelium, which can stimulate hair follicles, such as sonic hedgehog protein, WNT-1/ß-catenin, and epidermal growth factor receptor.

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来源期刊
American Journal of Case Reports
American Journal of Case Reports Medicine-Medicine (all)
CiteScore
1.80
自引率
0.00%
发文量
599
期刊介绍: American Journal of Case Reports is an international, peer-reviewed scientific journal that publishes single and series case reports in all medical fields. American Journal of Case Reports is issued on a continuous basis as a primary electronic journal. Print copies of a single article or a set of articles can be ordered on demand.
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