LIN28A/B 在肿瘤发生和发展中的作用研究取得进展。

Q3 Medicine

遗传 Pub Date : 2024-06-20 DOI:10.16288/j.yczz.24-056

Yi-Wen Zhang, Qin Huang, Yan-Yun Wu, Yue Sun, Yong-Long Wei

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引用次数: 0

摘要

LIN28A 及其同源物 LIN28B 是高度保守的 RNA 结合蛋白，在早期胚胎发育、体细胞重编程、新陈代谢和肿瘤发生中发挥重要作用。LIN28A/B 在乳腺癌等多种恶性肿瘤中高度表达。它们在肿瘤的发生、维持和转移过程中发挥重要作用，并与预后不良有关。以往的研究表明，LIN28A/B 的主要调控机制包括依赖 let-7s 的方式和独立于 let-7s 的方式，如直接靶向 mRNA。在这篇综述中，我们总结了 LIN28A/B 在肝癌、乳腺癌和结直肠癌等恶性肿瘤中的功能和分子调控机制，以期为进一步探索 LIN28A/B 的功能和机制及其在临床应用中可能发挥的作用提供参考。

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Progress on the role of LIN28A/B in tumor development and progression.

LIN28A and its homolog LIN28B are highly conserved RNA-binding proteins that play important roles in early embryonic development, somatic cell reprogramming, metabolism and tumorigenesis. LIN28A/B are highly expressed in a variety of malignant tumors such as breast cancer. They play important roles in the initiation, maintenance, and metastasis of tumors and are associated with poor prognosis. Previous studies have shown that the main regulatory mechanisms of LIN28A/B include let-7s dependent ways and let-7s independent ways, such as directly targeting mRNA. In this review, we summarize the function and molecular regulatory mechanisms of LIN28A/B in malignant tumors such as liver cancer, breast cancer and colorectal cancer, in order to provide references for further exploring the function and mechanism of LIN28A/B and their possible roles in clinical applications.

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来源期刊

遗传 Medicine-Medicine (all)

CiteScore

2.50

自引率

0.00%

发文量

6699

期刊介绍： Hereditas is a national academic journal sponsored by the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and the Chinese Society of Genetics and published by Science Press. It is a Chinese core journal and a Chinese high-quality scientific journal. The journal mainly publishes innovative research papers in the fields of genetics, genomics, cell biology, developmental biology, biological evolution, genetic engineering and biotechnology; new technologies and new methods; monographs and reviews on hot issues in the discipline; academic debates and discussions; experience in genetics teaching; introductions to famous geneticists at home and abroad; genetic counseling; information on academic conferences at home and abroad, etc. Main columns: review, frontier focus, research report, technology and method, resources and platform, experimental operation guide, genetic resources, genetics teaching, scientific news, etc.