开发基于正念的嗜睡症干预措施:可行性研究

IF 5.6 2区 医学 Q1 Medicine
Sleep Pub Date : 2024-10-11 DOI:10.1093/sleep/zsae137
Jennifer M Mundt, Phyllis C Zee, Matthew D Schuiling, Alec J Hakenjos, David E Victorson, Rina S Fox, Spencer C Dawson, Ann E Rogers, Jason C Ong
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引用次数: 0

摘要

研究目的:基于正念的干预(MBI)已被证明可以改善医疗人群的社会心理功能,但尚未对嗜睡症进行过研究。本研究考察了针对嗜睡症改编的 MBI 的可行性和可接受性,包括项目长度的三种变化:方法:患有嗜睡症的成人(N = 60)被随机分配到不同持续时间的 MBI 小组:简短(4 周)、标准(8 周)或延长(12 周)。参与者分别在基线、4 周、8 周和 12 周时完成评估。为了评估可行性和可接受性,主要结果包括出席率、冥想练习和数据完整性。此外,参与者还完成了对正念、自我同情、情绪、睡眠、社会心理功能和认知的测量。科恩氏 d ≥ 0.5 的效应大小被用作最小临床重要性差异(MCID)的预设基准:分别有 71.7%、61.7% 和 78.3% 的参与者达到了出勤率、冥想和数据完整性基准。与标准组相比,简短组和延长组达到这些基准的比例更高。所有小组在正念、自我同情、管理情绪的自我效能、积极的社会心理影响、整体心理健康和疲劳方面都达到了 MCID。标准组和扩展组在焦虑和抑郁方面达到了MCID标准,扩展组在社交和认知功能、白天嗜睡、嗜睡症状和嗜睡相关功能等其他方面达到了MCID标准:结果表明,在未来的临床试验中采用远程交付和数据收集方法是可行的,而且扩展 MBI 似乎能在保持冥想练习的出席率和参与度的同时提供最有利的临床影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of a mindfulness-based intervention for narcolepsy: a feasibility study.

Study objectives: Mindfulness-based interventions (MBI) have been shown to improve psychosocial functioning in medical populations but have not been studied in narcolepsy. This study examined the feasibility and acceptability of an MBI that was adapted for narcolepsy, including three variations in program length.

Methods: Adults with narcolepsy (N = 60) were randomized to MBI groups of varying durations: brief (4 weeks), standard (8 weeks), or extended (12 weeks). Participants completed assessments at baseline, 4, 8, and 12 weeks. To assess feasibility and acceptability, primary outcomes included attendance, meditation practice, and data completeness. Additionally, participants completed measures of mindfulness, self-compassion, mood, sleep, psychosocial functioning, and cognition. An effect size of Cohen's d ≥ 0.5 was used as the prespecified benchmark for a minimal clinically important difference (MCID).

Results: The attendance, meditation, and data completeness benchmarks were met by 71.7%, 61.7%, and 78.3% of participants, respectively. Higher proportions of the brief and extended groups met these benchmarks compared to the standard group. All groups met the MCID for mindfulness, self-compassion, self-efficacy for managing emotions, positive psychosocial impact, global mental health, and fatigue. Standard and extended groups met the MCID for anxiety and depression, and extended groups met the MCID for additional measures including social and cognitive functioning, daytime sleepiness, hypersomnia symptoms, and hypersomnia-related functioning.

Conclusions: Results suggest that the remote delivery and data collection methods are feasible to employ in future clinical trials, and it appears that the extended MBI provides the most favorable clinical impact while maintaining attendance and engagement in meditation practice.

Clinical trial registration: Awareness and Self-Compassion Enhancing Narcolepsy Treatment (ASCENT), NCT04306952, https://clinicaltrials.gov/ct2/show/NCT04306952.

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来源期刊
Sleep
Sleep Medicine-Neurology (clinical)
CiteScore
8.70
自引率
10.70%
发文量
0
期刊介绍: SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.
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