口服赛鲁米替尼能明显改善蜘蛛痣型先天性黑素细胞痣。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-01 Epub Date: 2024-06-17 DOI:10.1111/pde.15666

R Berna, T Hasbun, D Adams, A T Moon, J R Treat

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引用次数: 0

摘要

巨型先天性黑素细胞痣（GCMN）不仅影响美观，还可能导致黑素瘤。目前还没有针对 GCMN 的标准药物治疗方法。我们介绍了一例 8 岁女性患者的病例，她患有由 NRAS 基因突变引起的卡波状淋巴管瘤病，在口服色瑞替尼后，她的黑痣型 GCMN 病情有所好转。

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Significant improvement of a nevus spilus-type congenital melanocytic nevus with oral selumetinib.

Giant congenital melanocytic nevi (GCMN) can be cosmetically significant and can lead to melanoma. There is no standard pharmacologic treatment for GCMN. We present the case of an 8-year-old female with kaposiform lymphangiomatosis caused by an NRAS mutation whose nevus spilus-type GCMN improved on oral selumetinib.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.