聚焦分段纳秒 1064 纳米 Nd:YAG 激光的光学效应：人体皮肤应用技术。

IF 2.2 3区医学 Q2 DERMATOLOGY

Lasers in Surgery and Medicine Pub Date : 2024-06-18 DOI:10.1002/lsm.23812

Connie Liu, Hsin-Yi Huang, Yu-Yang Chang, Chi-Kuang Sun, Shih-Hsuan Chia, Yi-Hua Liao

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引用次数: 0

摘要

背景和目的：考虑到用于皮肤激光手术的皮秒激光和纳秒激光的脉宽相差约一个数量级，纳秒激光能否在人体皮肤中产生与皮秒激光引起的激光诱导光学击穿（LIOB）类似的光学效应？通过VISIA-CR成像、组织学检查和谐波发生显微镜（HGM）评估了聚焦部分纳秒1064纳米Nd:YAG激光诱导的皮肤变化：结果：聚焦的点阵纳秒 1064 纳米 Nd:YAG 激光可产生表皮空泡或真皮空洞，类似于皮秒激光产生的 LIOB 现象。光破坏的位置和程度可由激光能量和聚焦深度控制。此外，通过 HGM 成像还能观察到激光诱导的冲击波传播和乳头胶原的热变性：结论：聚焦点阵纳秒激光可在人体皮肤上产生类似于皮秒激光引起的 LIOB 的光学效应。通过应用技术，这种治疗方法能以可调方式诱导表皮和真皮修复机制，改善皮肤纹理、皱纹、疤痕和色素沉着，而不会破坏表皮表面。

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Optical Effects of Focused Fractional Nanosecond 1064-nm Nd:YAG Laser: Techniques of Application on Human Skin

Background and Objectives

Considering the pulse widths of picosecond and nanosecond lasers used in cutaneous laser surgery differ by approximately one order of magnitude, can nanosecond lasers produce the optical effect in human skin similar to laser-induced optical breakdown (LIOB) caused by picosecond lasers?

Methods

Cutaneous changes induced by a focused fractional nanosecond 1064-nm Nd:YAG laser were evaluated by VISIA-CR imaging, histological examination, and harmonic generation microscopy (HGM).

Results

A focused fractional nanosecond 1064-nm Nd:YAG laser can generate epidermal vacuoles or dermal cavities similar to the phenomenon of LIOB produced by picosecond lasers. The location and extent of photodisruption can be controlled by the laser fluence and focus depth. Moreover, laser-induced shock wave propagation and thermal degeneration of papillary collagen can be observed by HGM imaging.

Conclusion

Focused fractional nanosecond lasers can produce an optical effect on human skin similar to LIOB caused by picosecond lasers. With techniques of application, the treatment can induce epidermal and dermal repair mechanisms in a tunable fashion to improve skin texture, wrinkles, scars, and dyspigmentation, without disrupting the epidermal surface.

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来源期刊

Lasers in Surgery and Medicine 医学-外科

CiteScore

5.40

自引率

12.50%

发文量

119

审稿时长

1 months

期刊介绍： Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.