推动人类 1 型糖尿病动物模型的发展。

IF 7.8 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Cold Spring Harbor perspectives in medicine Pub Date : 2024-10-01 DOI:10.1101/cshperspect.a041587

David V Serreze, Jennifer R Dwyer, Jeremy J Racine

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引用次数: 0

摘要

目前已开发出多种啮齿动物模型来研究 1 型糖尿病（T1D）的发病基础，但非肥胖糖尿病（NOD）小鼠及其衍生品系仍是剖析 T1D 自身免疫反应基础的黄金标准。在此，我们回顾了 NOD 小鼠的发育起源，以及在过去几十年中，它们及其衍生品系是如何被用于剖析 T1D 的遗传和免疫致病基础的。本文还讨论了 NOD 小鼠和人类 T1D 免疫致病基础的相似或不同之处。此外，还回顾了为 "人性化 "NOD 小鼠及其衍生品系所做的努力，以便提供更好的模型来研究导致人类患者 T1D 的自身免疫反应。

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Advancing Animal Models of Human Type 1 Diabetes.

Multiple rodent models have been developed to study the basis of type 1 diabetes (T1D). However, nonobese diabetic (NOD) mice and derivative strains still provide the gold standard for dissecting the basis of the autoimmune responses underlying T1D. Here, we review the developmental origins of NOD mice, and how they and derivative strains have been used over the past several decades to dissect the genetic and immunopathogenic basis of T1D. Also discussed are ways in which the immunopathogenic basis of T1D in NOD mice and humans are similar or differ. Additionally reviewed are efforts to "humanize" NOD mice and derivative strains to provide improved models to study autoimmune responses contributing to T1D in human patients.

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来源期刊

Cold Spring Harbor perspectives in medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

14.30

自引率

1.90%

发文量

审稿时长

4-8 weeks

期刊介绍： Cold Spring Harbor Perspectives in Medicine is a monthly online publication comprising reviews on different aspects of a variety of diseases, covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.