骨质疏松症会增加死亡风险:前瞻性观察研究的系统回顾和荟萃分析。

IF 3.4 3区 医学 Q2 GERIATRICS & GERONTOLOGY
Nicola Veronese, Francesco Saverio Ragusa, Shaun Sabico, Ligia J Dominguez, Mario Barbagallo, Gustavo Duque, Nasser Al-Daghri
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引用次数: 0

摘要

背景与目的:骨肉疏松症是最近才被发现的一种老年综合症。骨肌肉疏松症与死亡风险之间的关联在很大程度上仍未得到充分探讨。在这篇对前瞻性队列研究进行荟萃分析的系统性综述中,我们旨在探讨骨肉疏松症是否与较高的死亡风险有关:我们在多个数据库中搜索了从开始到 2024 年 2 月 16 日有关骨肉疏松症和死亡率的前瞻性队列研究。我们使用现有的最经调整的估计值计算了骨质疏松症患者与对照组患者的死亡风险,并将数据汇总为风险比(RRs)及其 95% 置信区间(CIs)。所有分析均采用随机效应模型:在初步考虑的 231 项研究中,有 9 篇文章被排除在外,共纳入 14 429 名参与者(平均年龄:70 岁;64.5% 为女性)。骨肉疏松症的加权患病率为 12.72%。在平均 6.6 年的随访期间,在对平均四个协变量进行调整后,骨肉疏松症导致死亡风险增加约 53%(RR:1.53;95% CI:1.28-1.78)。考虑到发表偏倚后,重新计算的 RR 为 1.48(95%CI:1.23-1.72)。根据纽卡斯尔-渥太华量表(Newcastle Ottawa Scale),研究质量总体良好:结论:骨质疏松症与老年人死亡风险的增加密切相关,这表明有必要考虑到患有肌肉疏松症的患者是否存在骨质疏松症,反之亦然,因为这两种老年人的典型症状结合在一起可能会导致更多并发症,如死亡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Osteosarcopenia increases the risk of mortality: a systematic review and meta-analysis of prospective observational studies.

Osteosarcopenia increases the risk of mortality: a systematic review and meta-analysis of prospective observational studies.

Background & aims: Osteosarcopenia is a recently recognized geriatric syndrome. The association between osteosarcopenia and mortality risk is still largely underexplored. In this systematic review with meta-analysis of prospective cohort studies, we aimed to explore whether osteosarcopenia could be associated with a higher mortality risk.

Methods: Several databases were searched from the inception to 16th February 2024 for prospective cohort studies dealing with osteosarcopenia and mortality. We calculated the mortality risk in osteosarcopenia vs. controls using the most adjusted estimate available and summarized the data as risk ratios (RRs) with their 95% confidence intervals (CIs). A random-effect model was considered for all analyses.

Results: Among 231 studies initially considered, nine articles were included after exclusions for a total of 14,429 participants (mean age: 70 years; 64.5% females). The weighted prevalence of osteosarcopenia was 12.72%. Over a mean follow-up of 6.6 years and after adjusting for a mean of four covariates, osteosarcopenia was associated with approximately 53% increased risk of mortality (RR: 1.53; 95% CI: 1.28-1.78). After accounting for publication bias, the re-calculated RR was 1.48 (95%CI: 1.23-1.72). The quality of the studies was generally good, as determined by the Newcastle Ottawa Scale.

Conclusions: Osteosarcopenia was significantly linked with an increased risk of mortality in older people, indicating the need to consider the presence of osteoporosis in patients with sarcopenia, and vice versa, since the combination of these two conditions typical of older people may lead to further complications, such as mortality.

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来源期刊
CiteScore
7.90
自引率
5.00%
发文量
283
审稿时长
1 months
期刊介绍: Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.
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