眼周皮肤鳞状细胞癌新辅助治疗的点内甲氨蝶呤和新方法

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2024-11-01 DOI:10.1016/j.oftal.2024.05.006

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引用次数: 0

摘要

这项研究的目的是评估鞘内注射甲氨蝶呤（MTX）作为新辅助疗法治疗眼周鳞状细胞癌（SCC）的疗效和安全性。研究描述了一名患者在两次间隔两周的鞘内注射MTX后的疗效。对患者的治疗反应进行了评估，结果显示肿瘤明显缩小，随后对残余病灶进行了手术切除。MTX在眼周SCC的新辅助治疗中可能是一种有效而安全的选择。此外，我们还强调了免疫疗法在SCC治疗中日益增长的重要性，以及让专科医生熟悉这些新疗法的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Metotrexato intralesional y nuevos abordajes para la neoadyuvancia en el carcinoma escamoso cutaneo periocular

This study arises from the need to understand the different therapies for cutaneous squamous cell carcinoma (SCC), especially in challenging clinical situations where conventional therapeutic options may not be optimal.

The purpose of the study is to assess the efficacy and safety of intralesional methotrexate (MTX) as neoadjuvant therapy in the treatment of periocular SCC.

The outcome of a patient after two separate intralesional MTX infiltrations 2 weeks apart is described. Therapeutic response was evaluated, achieving a significant reduction in tumor size and subsequently performing surgical excision of the residual lesion. The procedure was well tolerated, with no local or distant recurrences in the follow up.

Intralesional MTX may be an effective and safe option in the neoadjuvant treatment of periocular SCC. Furthermore, we highlight the growing importance of immunotherapy in the approach to SCC and the need to familiarize specialists with these new treatments.

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来源期刊

Archivos De La Sociedad Espanola De Oftalmologia Medicine-Ophthalmology

CiteScore

1.20

自引率

0.00%

发文量

109

审稿时长

78 days

期刊介绍： La revista Archivos de la Sociedad Española de Oftalmología, editada mensualmente por la propia Sociedad, tiene como objetivo publicar trabajos de investigación básica y clínica como artículos originales; casos clínicos, innovaciones técnicas y correlaciones clinicopatológicas en forma de comunicaciones cortas; editoriales; revisiones; cartas al editor; comentarios de libros; información de eventos; noticias personales y anuncios comerciales, así como trabajos de temas históricos y motivos inconográficos relacionados con la Oftalmología. El título abreviado es Arch Soc Esp Oftalmol, y debe ser utilizado en bibliografías, notas a pie de página y referencias bibliográficas.