Association between IL6 rs1800795, IL10 rs1800871 and 1,800,872 polymorphisms with periodontitis

Background

The components of oral microorganisms are important for stimulating the production of pro-inflammatory cytokines, making it essential to understand this relationship. The purpose of this research was to investigate the relationship between polymorphisms of Interleukin 10 (IL-10) and Interleukin 6(IL-6) and candidiasis-type tooth decay.

Methods

Two hundred and forty individuals, including120 patients and 120 controls provided saliva and blood samples in accordance with ethical standards. Saliva samples were cultured on SDA and PDA to detect fungi, which were then identified using confirmatory tests. Additionally, blood samples were assayed to detect IL6 rs1800795, IL10 rs1800871 and rs1800872 genotypes. The relationship between these polymorphisms and candidiasis-type tooth decay was then investigated using the SPSS statistical program.

Results

Six types of dental caries were identified: Candida albicans (C.albicans) (75.25%), C. parapsilosis(20.58%), C. glabrata (4.54%), C. krusei (9.8%), Rhodotorula spp. (4.54%) and Penicillium spp. (5.44%). The allelic distribution of IL6 (−147 G/C) SNP (rs1800795) showed no statistically significant difference(P values for G/C and CC genotypes, respectively, p = 0.57 and p = 0.42). In addition, the presence The C allele increases the probability of contracting the disease by 1.3 times compared to the healthy group. But these effects are not statistically significant (P = 0.67). The rs1800871 T/C, it has no effect on the occurrence of the disease (OR = 0.37, 95% CI = 0.8–1.2). However, the C/C genotype increases the probability of tooth decay by 6 times (OR = 6, 95%, CI = 1.8–19.0, p = 0.01) and the C allele increases the likelihood of developing dental caries by 3.5 times (OR = 3.5, 95%, CI = 1.6–7.4) compared to the healthy group (p = 0.017).Also, the rs1800872 polymorphism, the A/C genotype does not have an effect on the incidence of the disease (OR = 0.44, 95% CI =0.1–1.97, p > 0.2) while the C/C genotype is more likely to suffer from caries. Caries increases 2.7 times compared to the AA genotype (OR = 2.7, 95% CI = 0.8–8.5, p = 0.09), and the C allele compared to the A allele increases the probability of periodontitis up to 2.4 times (OR = 2.4, 95% CI = 0.9–5.9, p = 0.05).

Conclusion

There may be a correlation between IL6 rs1800795, IL10 rs1800871 and 1,800,872 polymorphisms with periodontitis. However, further investigation with a larger sample size is needed to explore this relationship.