2015-2020 年哥伦比亚麦德林一家医疗机构对混合结缔组织病、原发性雷诺现象和系统性硬化症患者的毛细血管镜检查结果。

Q3 Health Professions

Revista Colombiana de Reumatologia Pub Date : 2025-07-01 DOI:10.1016/j.rcreu.2024.03.005

Adriana Margarita Trejos Tenorio , Carlos Jaime Velásquez Franco , Libia María Rodríguez Padilla , Miguel Antonio Mesa Navas

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引用次数: 0

摘要

甲襞毛细血管镜是评估微循环的有效工具。在混合性结缔组织病（MCTD）中，微血管的改变没有明确的定义。目的本研究旨在比较在一个毛细血管镜参考中心，混合性结缔组织病、系统性硬化症和原发性雷诺现象（pRP）患者的血管造影表现。材料与方法设计回顾性描述性研究，并结合探索性分析成分。临床和毛细血管检查特征信息来自医疗记录和专家毛细血管检查服务报告，使用Optilia 200x视频毛细血管镜。为了比较定性变量，在预期频率低于5的情况下，使用Pearson或Fisher精确卡方检验。结果回顾了120张毛细血管镜检查图。在MCTD组中，42.5%的患者表现为正常模式，37.5%的患者表现为非硬皮病模式，20%表现为硬皮病模式。pRP患者中62.5%为正常型，37.5%为非特异性型；两组均保持了毛细血管密度。在MCTS中，与SS相比，无血管区域较少(10% vs. 62.5%, P <；.001)，巨毛细血管(20% vs 100%, P <；.001)和出血(37.5% vs. 92.5%, P<；措施)。与SS组（5%）和pRP组（0%）相比，MCTD组以浓密毛细血管为主（10%），差异无统计学意义（P = 0.122）。结论与系统性硬化症相比，混合性结缔组织病毛细血管密度大，树形毛细血管出现频率高。

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Hallazgos capilaroscópicos en pacientes con enfermedad mixta del tejido conectivo, fenómeno de Raynaud primario y esclerosis sistémica en una institución en Medellín (Colombia), 2015-2020

Introduction

Nailfold capillaroscopy is a useful tool to evaluate microcirculation. In mixed connective tissue disease (MCTD), microvascular changes are not clearly defined.

Objective

This study aims to compare the angiographic findings between patients with mixed connective tissue disease, systemic sclerosis, and primary Raynaud phenomenon (pRP) in a capillaroscopy reference centre.

Materials and methods

A retrospective descriptive study with an exploratory analytical component was designed. Clinical and capillaroscopic characteristic information was obtained from medical records and capillaroscopic reports from an expert capillaroscopy service using an Optilia 200× videocapillaroscope. To compare qualitative variables, the Pearson or Fisher exact chi-square test was used in case of expected frequencies lower than five.

Results

One hundred and twenty capillaroscopy charts were reviewed. In the MCTD group, 42.5% of patients showed a normal pattern, 37.5% had a non-scleroderma pattern, and 20% exhibited a scleroderma pattern. Among pRP patients, 62.5% had a normal and 37.5% had a non-specific pattern; both groups preserved capillary density. In MCTS, compared to SS, there were fewer avascular areas (10% vs. 62.5%, P < .001), megacapillaries (20% vs 100%, P < .001), and haemorrhages (37.5 vs. 92.5%, P< .001). Bushy capillaries predominated in the MCTD (10%) compared to SS (5%) and pRP (0%) groups without significance difference (P = .122).

Conclusions

Compared to systemic sclerosis, mixed connective tissue disease presents greater capillary density and a greater frequency of arborescent capillaries.

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来源期刊

Revista Colombiana de Reumatologia Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Colombian Journal of Rheumatology (Revista Colombiana de Reumatología) is the official organ of the Colombian Association of Rheumatology (Asociación Colombiana de Reumatología) and the Central American, Caribbean and Andean Association of Rheumatology (Asociación Centroamericana Caribe Andina de Reumatología) - ACCA. It was created in December 1993 with the purpose of disseminating scientific information derived from primary and secondary research and presenting cases coming from the practice of Rheumatology in Latin America. Since its foundation, the Journal has been characterized by its plurality with subjects of all rheumatic and osteomuscular pathologies, in the form of original articles, historical articles, economic evaluations, and articles of reflection and education in Medicine. It covers an extensive area of topics ranging from the broad spectrum of the clinical aspects of rheumatology and related areas in autoimmunity (both in pediatric and adult pathologies), to aspects of basic sciences. It is an academic tool for the different members of the academic and scientific community at their different levels of training, from undergraduate to post-doctoral degrees, managing to integrate all actors inter and trans disciplinarily. It is intended for rheumatologists, general internists, specialists in related areas, and general practitioners in the country and abroad. It has become an important space in the work of all rheumatologists from Central and South America.