Physical and psychosocial factors associated with fatigue in individuals with 22q11.2 deletion syndrome

This study investigated fatigue in individuals with 22q11.2 deletion syndrome (22q11.2DS), identifying both physical and psychosocial factors.We conducted a cross‐sectional web‐based survey of 125 parents of individuals with 22q11.2DS. Significant factors of fatigue were identified using bivariate analysis and forward stepwise binary logistic regression.Overall, 34% (42 of 125) of the participants reported fatigue. Bivariate analysis identified 37 variables linked with fatigue, of which 11 were significant in multivariable analysis: older age (odds ratio [OR] = 1.28, 95% confidence interval [CI] [1.07, 1.53], P = 0.008), history of auditory hypersensitivity (OR = 36.4, 95% CI [4.08, 323.8], P = 0.001), delayed motor development (OR = 10.4, 95% CI [1.78, 61.0], P = 0.009), difficulty participating in events (OR = 33.5, 95% CI [1.1, 1068.2], P = 0.047), inability to join groups (OR = 47.9, 95% CI [4.8, 481.7], P = 0.001), concerns about marriage (OR = 17.0, 95% CI [2.6, 112.7], P = 0.003), inability to attend facilities (OR = 20.4, 95% CI [1.4, 308.0], P = 0.029), poor coordination when changing medical facilities (OR = < 0.010, 95% CI [0, 0.014], P = 0.002), lack of understanding about the individual's condition (OR = 0.010, 95% CI [0, 0.502], P = 0.021), and requirement of visiting multiple departments within the hospital (OR = 46.6, 95% CI [1.9, 1124.6], P = 0.018).Fatigue in 22q11.2DS is multifaceted, necessitating holistic fatigue management.