终生强迫症患者和健康对照组在 COVID-19 大流行期间的污染恐惧：一项纵向队列研究

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-01 DOI:10.1016/j.jocrd.2024.100889

Johanna A.M. du Mortier , Erik J. Giltay , Almar A.L. Kok , Patricia van Oppen , Merijn Eikelenboom , Didi Rhebergen , Richard C. Oude Voshaar , Anton J.L.M. van Balkom , Henny A.D. Visser

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引用次数: 0

摘要

背景COVID-19大流行可被视为一种 "症状激发试验"，可能会引发特定的强迫症和其他精神症状。因此，我们旨在比较大流行对三类人群中 COVID-19 恐惧、污染、抑郁和焦虑症状的长期影响：有大流行前污染症状和无大流行前污染症状的强迫症患者以及健康对照组。方法从 2020 年 4 月到 2022 年 2 月，我们对 138 名终生诊断为强迫症的患者和 373 名健康对照组进行了 16 次在线问卷调查。我们评估了与害怕 COVID-19、清洁强迫症、焦虑和抑郁症状相关的结果。使用混合模型，我们比较了有大流行前污染症状的强迫症患者、无此类症状的强迫症患者和健康对照组的发病轨迹。结果大流行前污染症状与较高的 COVID-19恐惧、污染症状、焦虑和抑郁症状明显相关。结论与对照组相比，只有大流行前有污染症状的强迫症患者才会对 COVID-19 和污染症状产生更多恐惧。由此看来，除非与强迫症的亚型有关，否则外部因素造成的压力不会引发强迫症症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Contamination fear during the COVID-19 pandemic in patients with lifetime obsessive compulsive disorder and healthy controls: A longitudinal cohort study

Background

The COVID-19 pandemic could be considered a 'symptom provocation test,' which may trigger specific OCD and other psychiatric symptoms. Therefore, we aimed to compare the long-term impact of the pandemic on fear of COVID-19, and contamination, depressive and anxiety symptoms in three groups: individuals with OCD with and without pre-pandemic contamination symptoms and healthy controls.

Methods

From April 2020 to February 2022, we administered 16 online questionnaires on 138 persons with a lifetime diagnosis of OCD and 373 healthy controls. We evaluated outcomes related to fear of COVID-19, cleaning obsessions and compulsions, anxiety, and depressive symptoms. Using mixed models, we compared the trajectories among persons with OCD who had pre-pandemic contamination symptoms, those without such symptoms, and healthy controls.

Results

Pre-pandemic contamination symptoms were significantly associated with higher fear of COVID-19, contamination symptoms, anxiety, and depressive symptoms. Persons with OCD without pre-pandemic contamination symptoms scored, on average, quite similarly to healthy controls.

Conclusions

Only in persons with pre-pandemic contamination symptoms did the pandemic provoke more fear of COVID-19 and contamination symptoms than in controls. It seems that stress caused by external factors, does not tri trigger OCD symptoms unless there is a connection to the subtype of OCD.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.