镁/铁-LDH:合成四氢螺[吡唑-4,5′-吡唑并[3,4-b]吡啶]衍生物的高效促进剂

IF 5.8 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Achraf Hibot , Hicham Fadili , Abderrafia Hafid , Jacques Lebreton , Maria Dolors Pujol , Mostafa Khouili
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引用次数: 0

摘要

该研究报告采用 Mg/Fe-LDH 作为异相催化剂合成了四氢螺[吡唑-4,5′-吡唑并[3,4-b]吡啶]衍生物。这种在碱性介质中使用镁/铁-LDH 催化剂缩合吡唑酮与醛的方法有很多优点,如使用可重复使用的低成本催化剂、环保条件、反应时间短和收率高。经过验证和确认,该催化剂相对稳定,无需额外处理即可重复使用。通过与不同的醛进行缩合,得到了双吡唑啉酮衍生物,纯化产物的收率从 71% 到 91%不等。所形成的加合物的立体阻抗阻止了后续的缩合反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Mg/Fe-LDH: An efficient promoter for the synthesis of tetrahydrospiro[pyrazole-4,5′-pyrazolo[3,4-b]pyridine] derivatives

Mg/Fe-LDH: An efficient promoter for the synthesis of tetrahydrospiro[pyrazole-4,5′-pyrazolo[3,4-b]pyridine] derivatives

The synthesis of tetrahydrospiro[pyrazole-4,5′-pyrazolo[3,4-b]pyridine] derivatives using Mg/Fe-LDH as a heterogeneous catalyst was reported. This methodology used for the condensation of pyrazolones with aldehydes in a basic medium and with the presence of the Mg/Fe-LDH catalyst presents many benefits, such as the fact of using a reusable and low-cost catalyst, environmentally friendly conditions, short reaction times and excellent yields. It has been verified and confirmed that the catalyst is relatively stable and allows its reuse without additional treatment. Condensation has been carried out with different aldehydes and bis-pyrazolone derivatives have been obtained with yields ranging from 71 to 91% of purified product. The stereo impedance of the adduct formed prevents subsequent condensation.

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来源期刊
Journal of Saudi Chemical Society
Journal of Saudi Chemical Society CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
8.90
自引率
1.80%
发文量
120
审稿时长
38 days
期刊介绍: Journal of Saudi Chemical Society is an English language, peer-reviewed scholarly publication in the area of chemistry. Journal of Saudi Chemical Society publishes original papers, reviews and short reports on, but not limited to: •Inorganic chemistry •Physical chemistry •Organic chemistry •Analytical chemistry Journal of Saudi Chemical Society is the official publication of the Saudi Chemical Society and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.
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