梅毒感染是宫颈阴道 HPV 发生的风险因素吗?病例对照研究

IF 4.7 3区 医学 Q1 INFECTIOUS DISEASES
Napoleão Moura Dias Neto , Vanessa Gonçalves Nunes Moura Dias , Denise Maria Christofolini
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引用次数: 0

摘要

背景梅毒和人乳头瘤病毒(HPV)是性传播疾病,影响着同一风险群体中的女性。因此,本研究的主要目的是调查HPV在梅毒患者和非梅毒患者中的流行情况,并观察合并感染时HPV宫颈病变的特征。研究还评估了与合并感染相关的社会人口学因素。研究方法这项病例对照研究是在巴西一家 HIV/STD 检测和培训中心进行的。研究组由患有梅毒(病例)和未患梅毒(对照)的妇女组成,按年龄配对。研究调查了HPV、HPV亚型和病变严重程度。所有女性都接受了社会人口学访谈、临床数据收集、细胞病理学分析细胞收集以及用于HPV诊断的混合捕获测试。统计分析采用卡方检验。研究结果样本包括 176 名妇女,每组 88 人。病例组(13 人)和对照组(16 人)的 HPV 感染率分别为 14.8%和 18.1%,两者之间没有显著的统计学差异。文盲在对照组中更为普遍(p = 0.023)。考虑到有提示性传播感染迹象的妇女,30%(6 人)的患者和对照组都感染了高危人类乳头瘤病毒,15%(3 人)有合并感染。细胞病理学评估显示,各组在细胞不典型性方面没有差异。然而,ASC-US 和 ASC-H(意义未定的高级别非典型鳞状细胞)只在合并感染的妇女中发现,其中 75% 的患者高危型 HPV 检测呈阳性。考虑到宫颈病变的分布,对高危型 HPV 患者(包括病例和对照组)的 HSIL(高级别上皮内病变)进行了评估。得出结论:HPV 感染率增加了:梅毒感染者的 HPV 感染率并没有增加。此外,合并感染似乎并不是宫颈癌前病变的加重因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is syphilis infection a risk factor for cervicovaginal HPV occurrence? A case-control study

Background

Syphilis and human papillomavirus (HPV) are sexually transmitted infections affecting women in the same risk group. Thus, the main objective of the present study was to investigate the prevalence of HPV in a population of women with and without syphilis and observe the characteristics of HPV cervical lesions when coinfection occurs. Sociodemographic factors associated with coinfection were also evaluated. Methods: This case-control study was conducted at a Brazilian HIV/STD testing and training center. Study groups were composed of women with (case) and without syphilis (control), paired by age. The presence of HPV, HPV subtype, and lesion severity were investigated. All women were subjected to a sociodemographic interview, clinical data collection, cell collection for cytopathological analysis, and a hybrid capture test for HPV diagnosis. The chi-square test was used for statistical analysis. Results: The sample consisted of 176 women, 88 in each group. The prevalence of HPV was 14.8 % in the case (n = 13) and 18.1 % in the control group (n = 16), and there was no statistically significant difference between them. Illiterate individuals were more prevalent in the control group (p = 0.023). Considering women with suggestive signs of STIs, 30 % (6) of the patients and controls had high-risk HPV, and 15 % (3) had coinfection. The cytopathological assessment showed no differences between the groups concerning cellular atypia. However, ASC-US and ASC-H (atypical squamous cells of undetermined significance and high-grade) were only found in women with coinfections, with 75 % of these patients testing positive for high-risk HPV. Considering the distribution of lesions on the cervix, the HSIL (high-grade intraepithelial lesion) was assessed in high-risk HPV patients, both cases and controls. Conclusions: The prevalence of HPV was not increased in patients infected with syphilis. In addition, coinfection does not seem to be an aggravating factor for the presence of precursor lesions of cervical cancer.

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来源期刊
Journal of Infection and Public Health
Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES
CiteScore
13.10
自引率
1.50%
发文量
203
审稿时长
96 days
期刊介绍: The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.
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