用于再生医学的器官生物打印技术的进展-文章

IF 10.1 1区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Engineering Pub Date : 2024-11-01 DOI:10.1016/j.eng.2024.04.023

Xiang Wang , Di Zhang , Yogendra Pratap Singh , Miji Yeo , Guotao Deng , Jiaqi Lai , Fei Chen , Ibrahim T. Ozbolat , Yin Yu

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引用次数: 0

摘要

由于人体的再生能力有限，受伤、疾病和衰老造成的器官损伤或衰竭带来了挑战。器官移植存在供体短缺和免疫排斥风险等问题，因此需要创新的解决方案。按需三维（3D）生物打印器官为组织工程和再生医学带来了希望。在这篇综述中，我们将探讨最先进的生物打印技术，重点是生物墨水和细胞类型的选择。随后，我们讨论了心脏、肝脏、肾脏和胰腺等实体器官生物打印的进展，强调了血管化和细胞整合的重要性。最后，我们将深入探讨生物打印器官的临床转化及其大规模生产所面临的主要挑战和未来发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Progress in Organ Bioprinting for Regenerative Medicine

Organ damage or failure arising from injury, disease, and aging poses challenges due to the body’s limited regenerative capabilities. Organ transplantation presents the issues of donor shortages and immune rejection risks, necessitating innovative solutions. The three-dimensional (3D) bioprinting of organs on demand offers promise in tissue engineering and regenerative medicine. In this review, we explore the state-of-the-art bioprinting technologies, with a focus on bioink and cell type selections. We follow with discussions on advances in the bioprinting of solid organs, such as the heart, liver, kidney, and pancreas, highlighting the importance of vascularization and cell integration. Finally, we provide insights into key challenges and future directions in the context of the clinical translation of bioprinted organs and their large-scale production.

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来源期刊

Engineering Environmental Science-Environmental Engineering

自引率

1.60%

发文量

335

审稿时长

35 days

期刊介绍： Engineering, an international open-access journal initiated by the Chinese Academy of Engineering (CAE) in 2015, serves as a distinguished platform for disseminating cutting-edge advancements in engineering R&D, sharing major research outputs, and highlighting key achievements worldwide. The journal's objectives encompass reporting progress in engineering science, fostering discussions on hot topics, addressing areas of interest, challenges, and prospects in engineering development, while considering human and environmental well-being and ethics in engineering. It aims to inspire breakthroughs and innovations with profound economic and social significance, propelling them to advanced international standards and transforming them into a new productive force. Ultimately, this endeavor seeks to bring about positive changes globally, benefit humanity, and shape a new future.