固体制剂综述片剂

N. verma, Uma Srivastava, Satya Prakash Singh, S. Yadav, Pragya Mishra
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引用次数: 0

摘要

片剂被定义为固体药物剂型,一般含有药物物质和适当的稀释剂,通过压片或模塑方法制备。片剂作为一种剂型一直很受欢迎,因为它对生产商(如制备简单、经济、稳定、便于包装、运输和分装)和患者都有好处。由于片剂的成分、制造方法或预期用途不同,片剂具有多种特性,因此片剂也有多种类别。片剂的配制和设计可以说是配制者确保在适当的时间、适当的剂量和适当的位置以适当的形式提供适量药物,同时保护其化学完整性的过程。生物利用率、生物等效性和验证等最新概念和法规对制剂设计和生产产生了影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Review on Solid Dosage form: Tablet
Tablet is defined as solid pharmaceutical dosage form containing drug substance generally with suitable diluents and prepared by either compression or molding methods. Tablets remain popular as a dosage form because of the advantages afforded, both to the manufacturer (e.g. simplicity and economy of the preparation, stability, and convenience in packing, shipping and dispensing) and the patient. Because of their composition, method of manufacture or intended use, tablets present a variety of characteristics and consequently there are several categories of tablets. Tablet formulation and design may be described as the process whereby the formulator ensures that the correct amount of the drug in the right form is delivered at or over the proper time at the proper rate and in the desired location, while having its chemical integrity protected to that point. Latest concepts and regulations focus on bioavailability, bioequivalence and validation etc. impact formulation designing and manufacture.
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