A STUDY ON TRANSFORAMINAL BLOCK COMPARISON OF TANSELONE AND DEXAMETHASONE

Objectives: To compare the efficacy and safety of Tanselone and Dexamethasone in TFESIs and provide guidance for their use, particularly for new pain specialists and postgraduate students. Methods: A prospective, randomized controlled trial was conducted, enrolling 100 patients with spinal pain syndromes randomized to receive either Tanselone or Dexamethasone in TFESIs. Pain intensity scores and functional outcomes were assessed at baseline and follow-up intervals (11). Adverse events related to TFESIs were monitored. Statistical analysis was performed to compare outcomes between the two groups. Results: Tanselone demonstrated superior efficacy in pain relief and functional improvement compared to Dexamethasone, with patients in the Tanselone group experiencing greater reductions in pain intensity scores and improvements in functional outcomes at all follow-up intervals. However, concerns were raised regarding the potential risk of vascular complications associated with Tanselone’s particulate nature. For new pain specialists and postgraduate students, Dexamethasone may be considered a safer alternative to minimize the risk of complications associated with TFESIs (11). A difference which was significant statistically in the Pain intensity score questionnaire (3.73±1.15 in group T, 6.55±0.51 in group Dx) and Oswestry disability index (18.67±7.13 in group T, 35.83±5.10 in group Dx) was found in both but was more in Tanselone group. Conclusion: By comparing Tanselone and dexamethasone for epidural injection, for the duration of analgesia of pain in lumbar radiculopathy, injection of Tanselone has been found to be more effective than injection of dexamethasone through transforaminal route. Clinicians should weigh the potential benefits of Tanselone’s efficacy against its perceived risks and consider using Dexamethasone, especially for novice practitioners, to minimize the risk of complications and ensure procedural safety in patients with spinal pain syndromes.