{"title":"纳米球精度:乳状液为癌症靶向治疗带来革命性变革","authors":"Meghna Dheek, Shikha Baghel Chauhan, Indu Singh","doi":"10.2174/0115748855299918240529063242","DOIUrl":null,"url":null,"abstract":"\n\nEmulsomes have gained attention because they are a novel lipoidal vesicular system that\nhas an internal solid fat core surrounded by a phospholipid bilayer. Cancer is a complex and broad\nterm that refers to a group of diseases characterized by the uncontrolled growth and spread of abnormal\ncells in the body. In the context of cancer targeting, emulsomes have shown promising potential\ndue to their ability to improve the solubility, stability, and bioavailability of anticancer drugs, leading\nto enhanced therapeutic efficacy and reduced systemic toxicity.\nThis article addresses emulsomal composition, preparation techniques, and different kinds of emulsomes\nloaded with drugs like fluvastatin and raloxifene hydrochloride to target cancer cells. The use\nof emulsomes in cancer targeting holds great promise for improving the precision, efficacy, and safety\nof cancer treatments.\nA comprehensive search of relevant scientific literature was performed. This involved searching databases\nsuch as PubMed, Scopus, Web of Science, and others to identify relevant studies, articles,\nand reviews related to the topic.\nEmulsomes loaded with specific drugs show promising results in cancer treatment. Examples include\npiceatannol-loaded emulsomes for colon cancer, raloxifene hydrochloride-loaded emulsomes for\nbreast cancer, and fluvastatin-loaded emulsomes for prostate cancer.\nEmulsomes represent a cutting-edge approach to cancer drug delivery, offering a versatile and effective\nsolution to address challenges associated with traditional anticancer formulations. 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引用次数: 0
摘要
乳状液体是一种新型的类脂囊泡系统,内部有一个由磷脂双分子层包围的固体脂肪核心,因此备受关注。癌症是一个复杂而宽泛的术语,指的是一组以异常细胞在体内不受控制地生长和扩散为特征的疾病。在癌症靶向治疗方面,乳状液因其能够提高抗癌药物的溶解度、稳定性和生物利用度,从而提高疗效并降低全身毒性,已显示出广阔的应用前景。本文介绍了乳状液的组成、制备技术,以及不同类型的乳状液载药(如氟伐他汀和盐酸雷洛昔芬)靶向治疗癌细胞的情况。乳状液在癌症靶向治疗中的应用为提高癌症治疗的精确性、有效性和安全性带来了巨大希望。我们对相关科学文献进行了全面搜索,包括搜索 PubMed、Scopus、Web of Science 等数据库,以确定与该主题相关的研究、文章和综述。乳状液是治疗癌症药物递送的前沿方法,为解决传统抗癌制剂所面临的挑战提供了一种多用途的有效解决方案。正在进行的研究为继续开发个性化癌症疗法带来了希望。
Nanosphere Precision: Emulsomes Revolutionizing Cancer Targeted Therapy
Emulsomes have gained attention because they are a novel lipoidal vesicular system that
has an internal solid fat core surrounded by a phospholipid bilayer. Cancer is a complex and broad
term that refers to a group of diseases characterized by the uncontrolled growth and spread of abnormal
cells in the body. In the context of cancer targeting, emulsomes have shown promising potential
due to their ability to improve the solubility, stability, and bioavailability of anticancer drugs, leading
to enhanced therapeutic efficacy and reduced systemic toxicity.
This article addresses emulsomal composition, preparation techniques, and different kinds of emulsomes
loaded with drugs like fluvastatin and raloxifene hydrochloride to target cancer cells. The use
of emulsomes in cancer targeting holds great promise for improving the precision, efficacy, and safety
of cancer treatments.
A comprehensive search of relevant scientific literature was performed. This involved searching databases
such as PubMed, Scopus, Web of Science, and others to identify relevant studies, articles,
and reviews related to the topic.
Emulsomes loaded with specific drugs show promising results in cancer treatment. Examples include
piceatannol-loaded emulsomes for colon cancer, raloxifene hydrochloride-loaded emulsomes for
breast cancer, and fluvastatin-loaded emulsomes for prostate cancer.
Emulsomes represent a cutting-edge approach to cancer drug delivery, offering a versatile and effective
solution to address challenges associated with traditional anticancer formulations. Ongoing research
holds promise for the continued development of personalized cancer therapy.
期刊介绍:
Current Drug Therapy publishes frontier reviews of high quality on all the latest advances in drug therapy covering: new and existing drugs, therapies and medical devices. The journal is essential reading for all researchers and clinicians involved in drug therapy.