代谢健康的肥胖与痴呆症风险之间的关系:系统回顾和荟萃分析

Medicine Advances Pub Date : 2024-06-07 DOI:10.1002/med4.57
Yanyi Su, Yuecai Li, Rongqi Ding, Ziyi Zheng, Jiaqi Wang, Qixiang Fu, Jialin Deng, Hong Zhou
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引用次数: 0

摘要

一些研究表明,与人类肥胖有关的新陈代谢改变可能会增加患痴呆症的可能性。然而,目前还没有关于代谢健康型肥胖(MHO)患者可能患痴呆症的荟萃分析。在本研究中,我们旨在调查 MHO 患者与痴呆症发病可能性之间的潜在相关性。我们的研究重点是搜索三个数据库,查找自 2023 年 1 月 10 日开始的相关研究。我们使用了敏感性分析、Egger 检验和可视化漏斗图来分别评估研究结果的可靠性和发表偏倚。我们根据 PROSPERO 注册表(CRD42023449459)中预先制定的方案开展了这项研究。与代谢健康但不肥胖的人相比,代谢健康且肥胖的人患痴呆症的可能性较低(危险比 (HR) = 0.79; 95% 置信区间 (CI) 0.68-0.92)。相比之下,代谢不健康但不肥胖的人患痴呆症的可能性增加(HR = 1.33; 95% CI 1.25-1.42),而代谢不健康的肥胖人群与痴呆症发病没有明显关联(HR = 1.06; 95% CI 0.83-1.37)。保持良好的新陈代谢有助于减少痴呆症的发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association between metabolically healthy obesity and risk of dementia: A systematic review and meta-analysis

Association between metabolically healthy obesity and risk of dementia: A systematic review and meta-analysis

Background

Some studies suggest that the metabolic alterations linked to obesity in humans may increase the likelihood of developing dementia. However, there are currently no existing meta-analyses exploring the possible occurrence of dementia in patients with metabolically healthy obesity (MHO). In the present study, we aimed to investigate a potential correlation between individuals with MHO and the likelihood of developing dementia.

Method

Our research focused on searching three databases to locate pertinent studies starting from January 10, 2023. We used sensitivity analysis, the Egger's test, and a visual funnel plot to separately assess the reliability of the research results and publication bias. We conducted this study according to a pre-established protocol in the PROSPERO registry (CRD42023449459).

Results

We incorporated three potential cohort investigations. Individuals with good metabolic health and obesity showed a decreased likelihood of developing dementia compared with those who were metabolically healthy but not obese (hazard ratio (HR) = 0.79; 95% confidence interval (CI) 0.68–0.92). In contrast, individuals who were metabolically unhealthy and nonobese had an increased likelihood of developing dementia (HR = 1.33; 95% CI 1.25–1.42), whereas the population with metabolically unhealthy obesity did not exhibit a notable association with dementia onset (HR = 1.06; 95% CI 0.83–1.37).

Conclusion

According to our meta-analysis, patients with MHO had a reduced likelihood of developing general dementia and Alzheimer disease. Maintaining a well-functioning metabolism can provide advantages in reducing the occurrence of dementia.

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