自闭症谱系障碍儿童和非自闭症谱系障碍儿童家长的广义自闭症表型和步态

IF 1.8 Q4 NEUROSCIENCES
Umer Jon Ganai, B. Bhushan, K. S. Venkatesh
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引用次数: 0

摘要

自闭症谱系障碍(ASD)是一种高度遗传性的神经发育障碍。研究表明,自闭症谱系障碍儿童的父母和亲属往往表现出类似自闭症谱系障碍的亚阈值特征,即广义自闭症表型(BAP),以及运动行为障碍。本研究旨在对 44 名 ASD 儿童的父母和 48 名发育正常儿童(TD)的父母的 BAP 特征和运动行为(即步态)进行研究。研究人员使用广泛的自闭症表型问卷(BAPQ)测量了自闭症儿童的BAP特征,并利用基于计算机视觉的低成本框架量化了自闭症儿童及其父母和发育迟缓儿童及其父母的步态。患有自闭症的儿童的父母在刻板性格和实用语言方面的得分一直明显较高,但两组父母在BAP特质的冷漠性格方面没有显著差异。在步态参数方面,与 TD 儿童的父母相比,ASD 儿童的父母步态速度较慢。在步态参数方面,患有自闭症的儿童及其父母的步态参数没有明显的相似之处。这些研究结果支持在 ASD 儿童的父母中存在类似 ASD 的特质,以及步速是 ASD 的一种假定运动内表型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Broad Autism Phenotype and Gait in Parents of Children With and Without Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder. Research has shown that parents and relatives of children with ASD often exhibit subthreshold ASD-like characteristics known as broad autism phenotype (BAP) as well as impairments in motor behaviours. The current study aimed to examine the BAP traits and motor behaviours, that is, gait in 44 parents of children with ASD and in 48 parents of typically developing children (TD). The BAP traits were measured using the broad autism phenotype questionnaire (BAPQ), and a low-cost computer vision-based framework was utilised to quantify the gait in children with ASD and their parents and TD children and their parents. The parents of children with ASD consistently displayed significantly higher scores on rigid personality and pragmatic language, however, there were no significant differences between the two group of parents on aloof personality of BAP traits. On gait parameters, the parents of children with ASD had a reduced gait speed in comparison to parents of TD children. There were no meaningful similarities in gait parameters of children with ASD and their parents. These findings support the presence of ASD-like traits in the parents of children with ASD and gait speed as a putative motor endophenotype of ASD.
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来源期刊
Annals of Neurosciences
Annals of Neurosciences NEUROSCIENCES-
CiteScore
2.40
自引率
0.00%
发文量
39
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