局部胃朗格汉斯细胞组织细胞增生症患者的临床特征和预后:病例系列

Tae-Se Kim, Soomin Ahn, Y. Min, Hyuk Lee, J. Lee, P. Rhee, Jae J. Kim, B. Min
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引用次数: 0

摘要

研究目的局部胃朗格汉斯细胞组织细胞增生症(LCH)的特征是胃中朗格汉斯细胞的异常增生,但没有全身受累,这种疾病非常罕见;因此,LCH的临床特征和预后仍不清楚。我们研究了被诊断为局部胃LCH患者的临床特征和预后,并探讨了这种罕见疾病的治疗策略:研究纳入了 1997 年 9 月至 2023 年 12 月期间在我院确诊的 7 例局部胃 LCH 患者。我们回顾性地查阅了病历,分析了临床病理特征和患者预后:内镜下,局部胃 LCH 表现为胃远端小糜烂。在治疗前的检查中,100.0%(4/4)的患者正电子发射计算机断层扫描结果显示正常。使用 S-100 和 CD1a 进行的免疫组化分析显示,所有受检患者的细胞均呈免疫阳性。在接受随访的六名患者中,有两名(33.3%)患者的复发部位与初始部位不同。不过,所有患者的病情最终都自然消退,随访期间也未观察到胃LCH引起的死亡:结论:对于没有全身受累的局部胃LCH患者来说,定期进行仔细监测就足够了。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical Characteristics and Outcomes in Patients With Localized Gastric Langerhans Cell Histiocytosis: A Case Series
Objectives: Localized gastric Langerhans cell histiocytosis (LCH) characterized by abnormal proliferation of Langerhans cells in the stomach without systemic involvement, is rare; therefore, the clinical characteristics and outcomes of LCH remain unclear. We investigated the clinical characteristics and outcomes in patients diagnosed with localized gastric LCH and have also discussed treatment strategies for this rare disease.Methods: The study included seven patients diagnosed with localized gastric LCH at our hospital between September 1997 and December 2023. We retrospectively reviewed medical records and analyzed the clinicopathological characteristics and patient outcomes.Results: Endoscopically, localized gastric LCH appeared as a small erosion in the distal part of the stomach. Positron emission tomography-computed tomography revealed normal findings in 100.0% (4/4) of patients during pre-treatment workup. Immunohistochemical analysis using S-100 and CD1a showed immunopositive cells in all tested patients. Of the six patients who underwent follow-up, two (33.3%) showed metachronous recurrence at a location distinct from the initial site. However, all patients eventually showed spontaneous regression of the disease, and no gastric LCH-induced mortality was observed during follow-up.Conclusions: Careful and regular surveillance may be sufficient for patients with localized gastric LCH without systemic involvement.
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