Hybrid Paper/Polyester-Based Laser-Induced Graphene Electrodes for Electrochemical Detection of Tadalafil

Here, we describe for the first time the fabrication of laser-induced graphene (LIG) electrodes on a hybrid substrate composed of sandpaper and polyester. As a proof of concept, the proposed device was used as a voltammetric sensor for tadalafil (TAD) quantification in authentic tablet samples. The electrochemical TAD sensing based on differential pulse voltammetry (DPV) revealed a linear behavior in the concentration range from 25 to 250 μmol L⁻¹(R²=0.99), a limit of detection of ~9.6 μmol L⁻¹, sensitivity of ~0.0048 μA(μmol L⁻¹)⁻¹ and acceptable reproducibility values (RSD≤5.8 %). The DPV responses involving the standard addition method in pharmaceutical samples presented recovery results of TAD ranging from 93 to 108 %. Also, the proposed analytical method offered a suitable green analytical chemistry profile. We successfully demonstrated the fabrication of graphene-like sites and nanoparticles composed of alumina upon a hybrid substrate.