桦木醇及其衍生物在伤口愈合中的作用及其临床特性

IF 0.3 Q4 PHARMACOLOGY & PHARMACY

Current Drug Therapy Pub Date : 2024-06-13 DOI:10.2174/0115748855311705240530073557

Esteban Zavaleta‐Monestel, Jonathan García-Montero, Sebastián Arguedas‐Chacón, Carolina Rojas-Chinchilla, Ricardo Quesada-Villaseñor, Renato Murillo

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引用次数: 0

摘要

目前，对有助于伤口愈合的各种天然产品的研究有了长足的发展。白桦脂及其衍生物白桦脂酸是一种三萜类化合物，在某些物种（如桦树）的叶子和树皮中含量丰富。临床和临床前研究表明，它们能够加速伤口愈合，还具有其他特性，如抗菌、抗炎作用和抗癌特性，以及对艾滋病、糖尿病和心血管疾病的有益作用。然而，为了更好地了解白桦脂和白桦脂酸的治疗潜力并开发出有效治疗的新药物，还需要进一步开展专门针对白桦脂和白桦脂酸的研究。这些研究进展将大大提高伤口、皮肤损伤和其他疾病的治疗效果，为改善人们的生活质量提供更有效、更安全的治疗选择。

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The Role of Betulin and its Derivative in Wound Healing and their Clinical Properties

Currently, studies on various natural products that aid in wound healing have seen significant growth. Betulin and its derivative, betulinic acid, are triterpenes abundant in the leaves and barks of certain species, such as birch, which has been of particular interest. Clinical and preclinical studies have demonstrated their ability to accelerate wound healing, as well as other properties such as antimicrobial, anti-inflammatory action, and anti-cancer properties, and beneficial effects on HIV, diabetes mellitus, and cardiovascular disorders. However, further research focusing exclusively on betulin and betulinic acid is needed to better understand its therapeutic potential and develop new medications for effective management. These advancements could greatly enhance the treatment of wounds, skin lesions and other diseases, offering more effective and safer therapeutic options to improve the quality of life of the population.

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来源期刊

Current Drug Therapy PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Drug Therapy publishes frontier reviews of high quality on all the latest advances in drug therapy covering: new and existing drugs, therapies and medical devices. The journal is essential reading for all researchers and clinicians involved in drug therapy.