一名使用奥克立珠单抗的多发性硬化症患者的大转子尿解支原体骨髓炎--病例报告

IF 1.8 Q3 INFECTIOUS DISEASES

Journal of Bone and Joint Infection Pub Date : 2024-06-13 DOI:10.5194/jbji-9-167-2024

Fred Ruythooren, S. Ghijselings, M. Depypere, W. Metsemakers, L. Henckaerts, Nathalie Noppe, G. Vles

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引用次数: 0

摘要

摘要用于治疗多发性硬化症（MS）的单克隆抗 CD20 抗体--奥克雷珠单抗（Ocrelizumab）在治疗自身免疫性疾病方面取得了重大进展，但却因低丙种球蛋白血症而增加了机会性感染的易感性。一名年轻的多发性硬化症患者因持续性尿解支原体尿道炎引发骨髓炎，经专门的聚合酶链反应确诊后，使用靶向抗生素治愈了该病。多学科方法对于治疗此类感染至关重要。

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Ureaplasma urealyticum osteomyelitis of the greater trochanter in a patient with multiple sclerosis using ocrelizumab – a case report

Abstract. Ocrelizumab – a monoclonal anti-CD20 antibody used in treatment of multiple sclerosis (MS) – marks significant progress in treating autoimmune diseases but raises susceptibility to opportunistic infections due to hypogammaglobulinemia. A young MS patient developed osteomyelitis from persistent Ureaplasma urealyticum urethritis, which was diagnosed with specialized polymerase chain reaction and resolved with targeted antibiotics. A multidisciplinary approach is crucial for managing such infections.

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来源期刊

Journal of Bone and Joint Infection Medicine-Surgery

CiteScore

3.70

自引率

0.00%

发文量

审稿时长

12 weeks