{"title":"不切除子宫的宫颈癌给药合剂化学免疫疗法：唤醒免疫细胞的免疫疗法","authors":"Baofa Yu, Feng Gao, Peng Jing, Guoqin Zheng, Yu Baofa","doi":"10.29011/2575-9760.11062","DOIUrl":null,"url":null,"abstract":"Background: Cervical cancer is one of the most common and deadly cancers in women, for whom with persistent infection of High-Risk Human Papillomavirus (HPV). Current treatment of cervical cancer involves radical hysterectomy, radiotherapy and chemotherapy or a combination. Objective: We to define if Hapten Enhanced Intratumoral Chemotherapy (HEIC) was effective in boosting immunity for effective treatment of cervical cancer lesions. Study Design: We used Single-Cell RNA Sequencing (scRNA-Seq) to obtain transcriptome profiles of 40239 cells from biopsies of cervical cancer lesions at the cervix directly from one patient before the start of HEIC and about 1 week after HEIC. The blood","PeriodicalId":515115,"journal":{"name":"Journal of Surgery","volume":"69 4","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hapten-Mediated Chemical Immune Therapy with Drug Administration into Cervical Cancer without Hysterectomy:Awakening Immune Cells for Immunotherapy\",\"authors\":\"Baofa Yu, Feng Gao, Peng Jing, Guoqin Zheng, Yu Baofa\",\"doi\":\"10.29011/2575-9760.11062\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Cervical cancer is one of the most common and deadly cancers in women, for whom with persistent infection of High-Risk Human Papillomavirus (HPV). Current treatment of cervical cancer involves radical hysterectomy, radiotherapy and chemotherapy or a combination. Objective: We to define if Hapten Enhanced Intratumoral Chemotherapy (HEIC) was effective in boosting immunity for effective treatment of cervical cancer lesions. Study Design: We used Single-Cell RNA Sequencing (scRNA-Seq) to obtain transcriptome profiles of 40239 cells from biopsies of cervical cancer lesions at the cervix directly from one patient before the start of HEIC and about 1 week after HEIC. The blood\",\"PeriodicalId\":515115,\"journal\":{\"name\":\"Journal of Surgery\",\"volume\":\"69 4\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29011/2575-9760.11062\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29011/2575-9760.11062","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Hapten-Mediated Chemical Immune Therapy with Drug Administration into Cervical Cancer without Hysterectomy:Awakening Immune Cells for Immunotherapy
Background: Cervical cancer is one of the most common and deadly cancers in women, for whom with persistent infection of High-Risk Human Papillomavirus (HPV). Current treatment of cervical cancer involves radical hysterectomy, radiotherapy and chemotherapy or a combination. Objective: We to define if Hapten Enhanced Intratumoral Chemotherapy (HEIC) was effective in boosting immunity for effective treatment of cervical cancer lesions. Study Design: We used Single-Cell RNA Sequencing (scRNA-Seq) to obtain transcriptome profiles of 40239 cells from biopsies of cervical cancer lesions at the cervix directly from one patient before the start of HEIC and about 1 week after HEIC. The blood
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