干血微量采样中的靶向和非靶向代谢组学和脂质组学:最新应用与展望

IF 3 Q2 CHEMISTRY, ANALYTICAL
Pauline Couacault, Dennisse Avella, Sara Londoño-Osorio, Ana S. Lorenzo, Ana Gradillas, Olli Kärkkäinen, Elizabeth Want, Michael Witting
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引用次数: 0

摘要

血液微采样(BµS)是使用血浆或血清分析人体健康状况的传统方法的替代方法,具有微创和成本效益高的特点,尤其有利于弱势群体。我们提交了一篇非系统性综述,概述了 2022 年和 2023 年干血微量取样在靶向和非靶向代谢组学和脂质组学研究中的分析方法、应用和前景。干血微量采样在新生儿和儿科研究、治疗药物监测、代谢物筛选、生物标记物研究、体育监督、临床疾病研究和法医毒理学等方面显示出潜力。值得注意的是,与其他体积计量技术相比,对干血点和体积计量吸收性微采样方案的研究更为广泛。因此,我们认为,进一步调查和应用体积技术将有助于使用 BµS 作为传统方法的替代方法。相反,我们也支持在使用 BµS 时统一分析方法将对其实施产生积极影响的观点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives

Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives

Blood microsampling (BµS) offers an alternative to conventional methods that use plasma or serum for profiling human health, being minimally invasive and cost effective, especially beneficial for vulnerable populations. We present a non-systematic review that offers a synopsis of the analytical methods, applications and perspectives related to dry blood microsampling in targeted and untargeted metabolomics and lipidomics research in the years 2022 and 2023. BµS shows potential in neonatal and paediatric studies, therapeutic drug monitoring, metabolite screening, biomarker research, sports supervision, clinical disorders studies and forensic toxicology. Notably, dried blood spots and volumetric absorptive microsampling options have been more extensively studied than other volumetric technologies. Therefore, we suggest that a further investigation and application of the volumetric technologies will contribute to the use of BµS as an alternative to conventional methods. Conversely, we support the idea that harmonisation of the analytical methods when using BµS would have a positive impact on its implementation.

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