通过 Hantzsch、Michael 和 Biginelli 反应合成由异丙醇单元连接的新型双杂环杂化物

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC

Arkivoc Pub Date : 2024-06-17 DOI:10.24820/ark.5550190.p012.209

Ismail A. Abdelhamid, Hadeer M. Diab, Nesma E. Mahmoud, Ahmed H. M. Elwahy, Ibrahim Fares

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引用次数: 0

摘要

将具有互补生物活性的化合物结合在一起以创造杂化分子是药物研究中的一个新想法。在这项工作中，我们创造了新型杂化分子，包括由异丙醇单元连接的双杂环。其方法是利用汉兹希反应、迈克尔反应和比吉内利反应，用适当的试剂缩合 4,4'-((2-羟基丙烷-1,3-二基)双(氧基))二苯甲醛。通过元素分析、1 H NMR、13 C NMR、IR 和 MS 光谱确定了新合成化合物的结构。

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Synthesis of New bis-Heterocyclic Hybrids linked by iso-propanol unit via Hantzsch, Michael, and Biginelli reactions

Combining compounds with complementary bioactivities to create hybrid molecules is a new idea in drug research. In this work, we created novel hybrid molecules including bis-heterocycles connected by an isopropanol unit. This is accomplished by the condensation of 4,4'-((2-hydroxypropane-1,3-diyl)bis(oxy))dibenzaldehyde with the appropriate reagents using Hantzsch, Michael, and Biginelli reactions. The structures of the newly synthesized compounds are determined by elemental analysis, 1 H NMR, 13 C NMR, IR, and MS spectra.

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来源期刊

Arkivoc 化学-有机化学

CiteScore

1.10

自引率

11.10%

发文量

120

审稿时长

3.1 months

期刊介绍： Arkivoc publishes full papers (not accounts) describing sound original work that is of interest to organic chemists (in areas of synthetic organic chemistry, bio-organic, organometallic, theoretical, and physical organic chemistry: General Papers describing sound original work Reviews and Accounts of selected topics Honorary Issues - Pay tribute to distinguished organic chemists (invited contributions) Thematic Issues - Cover important current topics in organic chemistry Regional Issues - Recognize organic chemistry in various countries.